Formation and spatio-temporal evolution of periodic structures in lipid bilayers.
Formation and spatio-temporal evolution of periodic structures in lipid bilayers.
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脂质双层周期性结构的形成和时空演化。
DOI：
10.1021/ja046300o
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发表时间：
2005
影响因子：
15
通讯作者：
J. Groves
中科院分区：
文献类型：
--
作者：
S. Rozovsky;Y. Kaizuka;J. Groves
脂双层中的混溶性相分离作为活细胞膜中的组织原理而被广泛涉及。然而，膜相分离如何调节蛋白质活性的化学和物理方面仍然不清楚。在这里，我们描述了形成有序的超结构共存的液相在双层膜。观察到亚稳条纹和六方畴晶格，以及它们之间的过渡。通过这些方法实现的高度有序便于域空间分布的统计分析，并使域相互作用的测量。这种长程有序原理可能存在于更复杂的膜系统中。
Miscibility phase separation in lipid bilayers is widely implicated as an organizing principle in living cell membranes. However, the chemical and physical aspects of how membrane phase separation modulates protein activity remain obscure. Herein, we describe formation of ordered superstructures of coexisting liquid phases in bilayer membranes. Metastable stripe and hexagonal domain lattices are observed, as well as transitions between them. The high degree of order achieved by these methods facilitates statistical analysis of domain spatial distributions and enables measurement of domain interactions. Such long-range ordering principles may exist in more complicated membrane systems.