Association between obesity and sexual maturation in Chinese children: a muticenter study
Association between obesity and sexual maturation in Chinese children: a muticenter study
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中国儿童肥胖与性成熟之间的关联：一项多中心研究
DOI：
10.1038/ijo.2014.116
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发表时间：
2014-10-01
影响因子：
4.9
通讯作者：
Chen, S. K.
中科院分区：
文献类型：
--
作者：
Dai, Y. L.;Fu, J. F.;Chen, S. K.
目的：我们旨在评估中国儿童性成熟的现状，探讨肥胖与男孩性成熟过早之间的关系，并将其与女孩进行比较，并检验这种关联因性别而异的假设。研究设计：横断面研究。对象：参与中国儿童青少年代谢综合征流行病学研究（7 月）的 6-18 岁男孩 9812 名和女孩 8895 名代表性样本2009年-2010年7月）进行了调查。方法：所有受试者都有完整的人体测量和性成熟数据。达到 Tanner 2 期或以上的受试者（5601 名男孩和 6538 名女孩）根据性成熟时间分为三分位数。将最早三分位的受试者纳入早熟组，将中间三分位和最晚三分位的受试者纳入非早熟组。超重定义为体重指数 (BMI)≥85%，肥胖≥95%。逻辑回归分析用于测试早熟如何影响超重风险。采用多元线性回归来检验肥胖（BMI Z 值）与性成熟之间的关联。结果：男孩肥胖略多于女孩（P<0.01）。 Tanner 2 阶段女孩的中位年龄为 9.69 岁，Tanner 2 阶段男孩的中位年龄为 11.25 岁。与非早熟者相比，早熟女孩和男孩的 BMI Z 分数均较高（P<0.01）。性成熟过早与女孩和男孩的肥胖呈正相关。调整协变量并以非早熟作为参考组，男孩的综合超重优势比为1.48，女孩为2.64，肥胖的优势比分别为男孩1.61和女孩3.49。结论：肥胖与男孩和女孩的性成熟呈正相关，且这种相关性在性别上没有差异，但女孩的相关性强于男孩。
Objective:We aimed to evaluate the current status of sexual maturation of Chinese children, to examine the association between obesity and early sexual maturation in boys and compare it with girls and to test the hypothesis that the associations differ by gender.Study Design:Cross-sectional study.Subjects:A representative sample involving 9812 boys and 8895 girls aged 6–18 years who participated in the Chinese Children and Adolescent Metabolic Syndrome Epidemiologic Study (July 2009–July 2010) were surveyed.Methods:All subjects had complete anthropometry and sexual maturation data. Subjects who reached Tanner stage 2 or more (5601 boys and 6538 girls) were divided into tertiles based on the timing of sexual maturation. The subjects in the earliest tertile were included into the early-maturing group, and the middle tertile and the latest tertile into the not early-maturing group. Overweight was defined as a body mass index (BMI)⩾ 85th percentile and obesity⩾ 95th percentile. Logistic regression analysis was used to test how early maturation affected the risk of overweight. Multiple linear regression was used to examine the association between fatness (BMI Z-score) and sexual maturation.Results:Slightly more boys were obese than girls (P< 0.01). The median age for girls of the Tanner stage 2 was 9.69 years, and for boys of Tanner stage 2 was 11.25 years. BMI Z-score were higher (P< 0.01) in both early-maturing girls and boys, compared with the non-early maturers, respectively. Early sexual maturation was positively associated with obesity in both girls and boys. With covariates adjusted and using non-early maturing as the reference group, odds ratios for combined overweight were 1.48 for boys and 2.64 for girls, and for obesities were 1.61 for boys and 3.49 for girls, respectively.Conclusion:Obesity is positively associated with sexual maturation in both boys and girls, and the association does not differ by gender, but the association is stronger in girls than in boys.