The definition of anemia in older persons
The definition of anemia in older persons
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DOI：
10.1001/jama.281.18.1714
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发表时间：
1999-05-12
影响因子：
120.7
通讯作者：
Knook, DL
中科院分区：
文献类型：
--
作者：
Izaks, GJ;Westendorp, RGJ;Knook, DL
背景世界卫生组织(WHO)定义为贫血的血红蛋白浓度是否与老年人死亡率的增加有关尚不清楚。目的调查老年人血红蛋白浓度与原因特异性死亡率之间的关系。设计1986年至1996年(随访10年)进行的基于社区的研究。研究对象为荷兰莱顿。共有1016名85岁及以上的社区居民符合条件，872人同意采集血样。对755人(74%)的血红蛋白浓度进行了测量，主要结果衡量了血红蛋白浓度、10年存活期和主要死因。根据WHO标准，贫血定义为女性<7.5mmo1/L(120g/L)，男性<8.1mmoL/L(130g/L)。结果与血红蛋白浓度正常者相比，死亡风险为1.6(95%可信区间，1.24~2.06；P
Context Whether hemoglobin concentrations defined as anemia by the World Health Organization (WHO) are associated with increased mortality in older persons is not known.Objective To investigate the association between hemoglobin concentration and cause-specific mortality in older persons.Design Community-based study conducted from 1986 to 1996 (follow-up period, 10 years).Setting Leiden, the Netherlands.Participants A total of 1016 community residents aged 85 years and older were eligible and 872 agreed to have a blood sample taken. Hemoglobin concentration was measured in 755 persons (74%),Main Outcome Measures Hemoglobin concentration, 10-year survival, and primary cause of death. According to the WHO criteria, anemia was defined as a hemoglobin concentration below 7.5 mmol/L (120 g/L) in women and below 8.1 mmol/L (130 g/L) in men.Results Compared with persons with a normal hemoglobin concentration, the mortality risk was 1.60 (95% confidence interval [CI], 1.24-2.06; P