Changes in interleukin-1β and 6 after hepatic microwave tissue ablation compared with radiofrequency, cryotherapy and surgical resections
Changes in interleukin-1β and 6 after hepatic microwave tissue ablation compared with radiofrequency, cryotherapy and surgical resections
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DOI：
10.1016/j.amjsurg.2009.12.025
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发表时间：
2010-10-01
影响因子：
3
通讯作者：
Lloyd, David M.
中科院分区：
文献类型：
--
作者：
Ahmad, Fateh;Gravante, Gianpiero;Lloyd, David M.
背景技术背景：比较微波组织消融术（MTA）与肝切除术、射频消融术（RFA）、热疗术（TACE）后细胞因子的变化。细胞因子的生产进行了测量，在各种消融体积的每一种方式和相关的过渡性炎症区产生的消融technology.METHODS：活大鼠进行MTA，手术切除，CRY（）或RFA的15%，33%，或66%的总肝体积。在术前和术后1、3、6、24和48小时采集血清样本，分析促炎细胞因子白细胞介素（IL）-1 β和IL-6。结果：与MTA、肝切除术或对照组相比，CRY和RFA后两种细胞因子的水平显著升高（P <0.001）。所有动物均存活，但接受RFA或66%肝体积RFA或CABG的动物除外，其在6小时内死亡。RFA后产生的过渡区大于那些后CASTO或MTA，但没有相关性存在与细胞因子的量。结论：大容量MTA与一个显着降低细胞因子反应，是耐受性良好的RFA和CASTO相比。(C)2010年爱思唯尔公司All rights reserved.
BACKGROUND: Cytokine changes after microwave tissue ablation (MTA) were compared with hepatic resection, eryotherapy (CRYO), and radiofrequency ablation (RFA). Cytokine production was measured at various ablation volumes for each modality and correlated with the transitional inflammatory zone produced by the ablation techniques.METHODS: Live rats underwent MTA, surgical resection, CRY() or RFA of 15%, 33%, or 66% of the total hepatic volume. Serum samples were collected preoperatively and at 1, 3, 6, 24, and 48 hours after surgery and analyzed for pro-inflammatory cytokines interleukin (IL)-1 beta and IL-6.RESULTS: Significantly higher levels of both cytokines were present after CRY and RFA compared with MTA, hepatic resection, or controls (P < .001). All animals survived except those undergoing RFA or CRYO of 66% of the hepatic volume, which died within 6 hours. Transitional zones produced after RFA were larger than those after CRYO or MTA, but no correlation was present with the amount of cytokines.CONCLUSIONS: Large-volume MTA is associated with a significant decreased cytokine response and is well tolerated compared with RFA and CRYO. (C) 2010 Elsevier Inc. All rights reserved.