Design of cucurbit[6]uril-based hypercrosslinked polymers for efficient capture of albendazole
Design of cucurbit[6]uril-based hypercrosslinked polymers for efficient capture of albendazole
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DOI：
10.1016/j.seppur.2019.01.065
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发表时间：
2019-06
影响因子：
8.6
通讯作者：
Dongze Wang;Xuemei Li;Xiangqun Jin;Q. Jia
中科院分区：
文献类型：
--
作者：
Dongze Wang;Xuemei Li;Xiangqun Jin;Q. Jia
在本研究中，葫芦[6]脲基超交联聚合物（HCPs）的成功合成和用于捕获阿苯达唑，一种广谱驱虫药。采用傅里叶变换红外光谱、元素分析、粉末X射线衍射、扫描电镜、热重分析和N2吸附-脱附测试等手段证明了所需HCP的成功制备。由于六元瓜环对阿苯达唑的包封作用和HCP的高比表面积，使得对阿苯达唑的吸附能力显著提高。吸附行为符合Langmuir吸附等温线，吉布斯自由能变化为负值，表明吸附过程为自发过程。此外，还研究了阿苯达唑的吸附动力学，其吸附动力学符合准二级动力学模型。
In the present study, cucurbit[6]uril-based hypercrosslinked polymers (HCPs) were successfully synthesized and employed for the capture of albendazole, a broad-spectrum anthelmintic drug. Fourier-transform infrared spectroscopy, elemental analysis, powder X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, and N2adsorption-desorption measurements were used to prove the successful preparation of the desired HCPs. Thanks to the encapsulation of cucurbit[6]uril toward albendazole and the high surface area of HCPs, remarkable adsorption capacity of albendazole was achieved. The adsorption behavior followed Langmuir adsorption isotherm with a negative value of Gibbs free energy change, suggesting a spontaneous adsorption process. In addition, the kinetics of albendazole adsorption was investigated, which could be described with the pseudo-second-order kinetics model.