Hydroxyl Group-Directed Organocatalytic Asymmetric Michael Addition of α,β-Unsaturated Ketones with Alkenylboronic Acids
Hydroxyl Group-Directed Organocatalytic Asymmetric Michael Addition of α,β-Unsaturated Ketones with Alkenylboronic Acids
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DOI：
10.1021/ol9006053
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发表时间：
2009-06-04
期刊：
影响因子：
5.2
通讯作者：
Takemoto, Yoshiji
中科院分区：
文献类型：
--
作者：
Inokuma, Tsubasa;Takasu, Kiyosei;Takemoto, Yoshiji
证明了在亚氨基酚型硫脲催化剂存在下有机硼酸与γ-羟基烯酮的有机催化不对称迈克尔加成。底物中的羟基在此反应中起着至关重要的作用。
The organocatalytic asymmetric Michael addition of organoboronic acids to gamma-hydroxy enones in the presence of an iminophenol-type thiourea catalyst is demonstrated. The hydroxyl group in the substrates plays a critical role in this reaction.