Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment.
Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment.
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DOI：
10.1186/s13195-021-00804-9
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发表时间：
2021-03-27
期刊：
影响因子：
--
通讯作者：
Hansson O
中科院分区：
文献类型：
--
作者：
Cicognola C;Janelidze S;Hertze J;Zetterberg H;Blennow K;Mattsson-Carlgren N;Hansson O
血浆胶质纤维酸性蛋白 (GFAP) 是星形胶质细胞活化和星形细胞增多的标志物。我们评估了血浆 GFAP 在轻度认知障碍 (MCI) 队列中检测 AD 相关淀粉样蛋白-β (Aβ) 病理形式的阿尔茨海默病 (AD) 病理以及转化为 AD 痴呆的能力。 160 名 MCI 患者的随访时间为 4.7 年（平均）。 AD 病理学使用脑脊液 (CSF) Aβ42/40 和 Aβ42/总 tau (T-tau) 进行定义。使用 Simoa 技术在基线和随访时测量血浆 GFAP。基线血浆 GFAP 可以检测异常的 CSF Aβ42/40 和 CSF Aβ42/T-tau，AUC 分别为 0.79 (95% CI 0.72–0.86) 和 0.80 (95% CI 0.72–0.86)。当还包括 APOE ε4 状态作为预测因子时，模型检测异常 CSF Aβ42/40 状态的准确性得到提高（AUC = 0.86，p = 0.02）。血浆 GFAP 预测随后转变为 AD 痴呆的 AUC 为 0.84 (95% CI 0.77–0.91)，当在模型中添加 APOE ε4 或年龄作为预测因子时，这一结果并没有显着改善。进展为痴呆（AD 或其他）的 Aβ 阳性和 MCI 的纵向 GFAP 斜率分别显着高于 Aβ 阴性 (p = 0.007) 和稳定 MCI (p < 0.0001) 的纵向 GFAP 斜率。血浆 GFAP 可以检测 MCI 患者的 AD 病理并预测转化为 AD 痴呆。
Plasma glial fibrillary acidic protein (GFAP) is a marker of astroglial activation and astrocytosis. We assessed the ability of plasma GFAP to detect Alzheimer’s disease (AD) pathology in the form of AD-related amyloid-β (Aβ) pathology and conversion to AD dementia in a mild cognitive impairment (MCI) cohort. One hundred sixty MCI patients were followed for 4.7 years (average). AD pathology was defined using cerebrospinal fluid (CSF) Aβ42/40 and Aβ42/total tau (T-tau). Plasma GFAP was measured at baseline and follow-up using Simoa technology. Baseline plasma GFAP could detect abnormal CSF Aβ42/40 and CSF Aβ42/T-tau with an AUC of 0.79 (95% CI 0.72–0.86) and 0.80 (95% CI 0.72–0.86), respectively. When also including APOE ε4 status as a predictor, the accuracy of the model to detect abnormal CSF Aβ42/40 status improved (AUC = 0.86, p = 0.02). Plasma GFAP predicted subsequent conversion to AD dementia with an AUC of 0.84 (95% CI 0.77–0.91), which was not significantly improved when adding APOE ε4 or age as predictors to the model. Longitudinal GFAP slopes for Aβ-positive and MCI who progressed to dementia (AD or other) were significantly steeper than those for Aβ-negative (p = 0.007) and stable MCI (p < 0.0001), respectively. Plasma GFAP can detect AD pathology in patients with MCI and predict conversion to AD dementia.
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DOI：
10.1097/nen.0b013e318217a118
发表时间：
2011-05
影响因子：
3.2
作者：
DaRocha-Souto B;Scotton TC;Coma M;Serrano-Pozo A;Hashimoto T;Serenó L;Rodríguez M;Sánchez B;Hyman BT;Gómez-Isla T
通讯作者：
Gómez-Isla T
DOI：
10.1016/s1474-4422(12)70228-4
发表时间：
2012-12
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Reiman EM;Quiroz YT;Fleisher AS;Chen K;Velez-Pardo C;Jimenez-Del-Rio M;Fagan AM;Shah AR;Alvarez S;Arbelaez A;Giraldo M;Acosta-Baena N;Sperling RA;Dickerson B;Stern CE;Tirado V;Munoz C;Reiman RA;Huentelman MJ;Alexander GE;Langbaum JB;Kosik KS;Tariot PN;Lopera F
通讯作者：
Lopera F
影响因子：
6.8
作者：
Chatterjee P;Pedrini S;Stoops E;Goozee K;Villemagne VL;Asih PR;Verberk IMW;Dave P;Taddei K;Sohrabi HR;Zetterberg H;Blennow K;Teunissen CE;Vanderstichele HM;Martins RN
通讯作者：
Martins RN
影响因子：
4
作者：
Oeckl, Patrick;Halbgebauer, Steffen;Otto, Markus
通讯作者：
Otto, Markus
影响因子：
9.3
作者：
Carter, Stephen F.;Scholl, Michael;Nordberg, Agneta
通讯作者：
Nordberg, Agneta