Root resorption and the OPG/RANKL/RANK system: a mini review.
Root resorption and the OPG/RANKL/RANK system: a mini review.
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DOI：
10.2334/josnusd.50.367
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发表时间：
2008-12
影响因子：
1.9
通讯作者：
J. B. Tyrovola;M. Spyropoulos;M. Makou;D. Perrea
中科院分区：
文献类型：
--
作者：
J. B. Tyrovola;M. Spyropoulos;M. Makou;D. Perrea
牙根再生是影响正畸牙齿运动的重要临床问题，而乳牙牙根再生是一种有趣的生物学现象。OPG/RANKL/RANK系统的功能协调似乎不仅有助于牙槽骨重塑，还有助于正畸牙齿运动过程中的吸收和生理性牙根吸收。血清OPG和s-RANKL与OPG/RANKL/RANK系统对骨稳态的调节有关，测定其浓度可能有助于预测正畸牙齿运动过程中骨重塑的速度、骨重塑与牙根吸收的净效应以及牙根吸收的程度。因此，我们有理由推测，使用健康的实验动物和精心策划和组织的实验设计，研究正畸牙齿移动过程中血液和GCF中OPG和s-RANKL水平与牙根吸收程度的关系，可能能够回答这个有趣的问题。
Odontoclastic root resorption is a significant clinical issue in relation to orthodontic tooth movement, and resorption of the roots of primary teeth is an intriguing biological phenomenon. The functional coordination of the OPG/RANKL/RANK system seems to contribute not only to alveolar remodeling, but also to resorption during orthodontic tooth movement and physiological root resorption. Serum OPG and s-RANKL are related to regulation of bone homeostasis by the OPG/RANKL/RANK system, and determination of their concentrations might be useful for predicting the rate of bone remodeling during orthodontic tooth movement, the net effect between bone remodeling and root resorption, and the degree of root resorption. It is therefore rational to speculate that a study of the levels of OPG and s-RANKL in blood and GCF, in relation to the degree of root resorption during orthodontic tooth movement, using healthy experimental animals and a carefully planned and organized experimental design, may be able to answer this intriguing question.