Effect of hematocrit reduction on hormonal and metabolic responses to exercise.
Effect of hematocrit reduction on hormonal and metabolic responses to exercise.
复制标题
血细胞比容降低对运动的激素和代谢反应的影响。
DOI：
10.1152/jappl.1985.58.4.1257
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发表时间：
1985
影响因子：
3.3
通讯作者：
M. Vranic
中科院分区：
文献类型：
--
作者：
D. Wasserman;H. Lavina;A. Lickley;M. Vranic
我们希望确定在运动过程中降低25%的红细胞压积对糖调节激素释放和葡萄糖流量的影响。在90分钟的运动期结束时，5只贫血狗的血糖下降了21毫克/分升，而5只对照组的血糖下降了7毫克/分升。运动50min后，贫血患者的肝脏葡萄糖生成量(Ra)和葡萄糖代谢清除率(MCR)开始不成比例地升高。运动结束时，RA值增加近3倍(Delta 15.1+/-3.4比Delta 5.2+/-1.3 mg X kg-1X min-1)，MCR增加近4倍(Delta 24.6+/-8.8比Delta 6.5+/-1.3mlX kg-1X min-1)。与对照组相比，与对照组相比，贫血运动导致高血糖素[免疫反应性高血糖素(IRG)增量1,283+/-507比增量514+/-99 pg/ml]，去甲肾上腺素(增量1,592+/-280比增量590+/-155 pg/ml)，肾上腺素(增量2,293+/-994比增量385+/-186 pg/ml)，90分钟后皮质醇(增量6.7+/-2.2比增量2.1+/-1.0微克/分升)和乳酸(增量12.1+/-2.2比增量4.2+/-1.8毫克/分升)。免疫活性胰岛素和游离脂肪酸在两组中相似。总之，红细胞压积降低25%的运动导致1)乳酸、去甲肾上腺素、肾上腺素、皮质醇和IRG水平升高，2)Ra增加，这可能与反调节反应增加有关，3)我们推测MCR增加近四倍与工作肌肉缺氧引起的代谢变化有关。
We wished to determine the effect of a 25% hematocrit reduction on glucoregulatory hormone release and glucose fluxes during exercise. In five anemic dogs, plasma glucose fell by 21 mg/dl and in five controls by 7 mg/dl by the end of the 90-min exercise period. After 50 min of exercise, hepatic glucose production (Ra) and glucose metabolic clearance rate (MCR) began to rise disproportionately in anemics compared with controls. By the end of exercise, the increase in Ra was almost threefold higher (delta 15.1 +/- 3.4 vs. delta 5.2 +/- 1.3 mg X kg-1 X min-1) and MCR nearly fourfold (delta 24.6 +/- 8.8 vs. delta 6.5 +/- 1.3 ml X kg-1 X min-1). Exercise with anemia, in relation to controls resulted in elevated levels of glucagon [immunoreactive glucagon (IRG) delta 1,283 +/- 507 vs delta 514 +/- 99 pg/ml], norepinephrine (delta 1,592 +/- 280 vs. delta 590 +/- 155 pg/ml), epinephrine (delta 2,293 +/- 994 vs. delta 385 +/- 186 pg/ml), cortisol (delta 6.7 +/- 2.2 vs. delta 2.1 +/- 1.0 micrograms/dl) and lactate (delta 12.1 +/- 2.2 vs. delta 4.2 +/- 1.8 mg/dl) after 90 min. Immunoreactive insulin and free fatty acids were similar in both groups. In conclusion, exercise with a 25% hematocrit reduction results in 1) elevated lactate, norepinephrine, epinephrine, cortisol, and IRG levels, 2) an increased Ra which is likely related to the increased counterregulatory response, and 3) we speculate that a near fourfold increase in MCR is related to metabolic changes due to hypoxia in working muscle.(ABSTRACT TRUNCATED AT 250 WORDS)