Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation
Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation
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DOI：
10.1016/j.ejphar.2008.06.066
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发表时间：
2008-09-04
影响因子：
5
通讯作者：
Liu, Zhenguo
中科院分区：
文献类型：
--
作者：
Chu, Ling;Jiang, Yuehua;Liu, Zhenguo
本研究旨在探讨一氧化氮（NO）在骨髓干细胞体外分化为内皮细胞中的作用。成年小鼠骨髓多能祖细胞（MAPCs）被用作干细胞的来源。NO供体NONOate或硝普钠（SNP）以浓度依赖性方式孵育MAPCs后，Oct-4表达（mRNA和蛋白）显著增加，最高达68.0%（n=3，P
This study was designed to investigate the role of nitric oxide (NO) in bone marrow stem cells and their differentiation into endothelial cells in vitro. Adult mouse bone marrow multipotent progenitor cells (MAPCs) were used as the source of stem cells. Oct-4 expression (both mRNA and protein) was significantly increased by up to 68.0% in MAPCs when incubated with NO donors DETA-NONOate or sodium nitroprusside (SNP) in a concentration-dependant manner (n=3, P