pO polarography, contrast enhanced color duplex sonography (CDS), [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography:: validated methods for the evaluation of therapy-relevant tumor oxygenation or only bricks in the puzzle of tumor hypoxia?
pO polarography, contrast enhanced color duplex sonography (CDS), [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography:: validated methods for the evaluation of therapy-relevant tumor oxygenation or only bricks in the puzzle of tumor hypoxia?
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DOI：
10.1186/1471-2407-7-113
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发表时间：
2007-06-28
期刊：
影响因子：
3.8
通讯作者：
Eble, Michael J.
中科院分区：
文献类型：
--
作者：
Gagel, Bernd;Piroth, Marc;Eble, Michael J.
背景：本研究分析[F-18]-氟异硝唑(FMISO)和[F-18]-2-氟-2‘-脱氧葡萄糖(FDG)正电子发射计算机断层扫描([F-18]-2-氟-2’-脱氧葡萄糖(FDG))和彩色双功超声(CDS)评价的彩色像素密度(CPD)和肿瘤血流灌注(TP)在判断治疗相关性低氧中的价值。作为测量人体肿瘤组织氧合的标准，采用有创极谱极谱电极系统(Po(2)组织成像)对不同的非侵入性测量方法进行了比较。用Po(2)组织描记仪测量肿瘤组织Po(2)。针电极在肿瘤内放置CT控制，无需全身或局部麻醉。为了评估氧合测量的生物学和临床相关性，Po(2)读数的相对频率
Background: The present study was conducted to analyze the value of ([F-18] fluoromisonidazole (FMISO) and [F-18]-2-fluoro-2'-deoxyglucose (FDG) PET as well as color pixel density (CPD) and tumor perfusion (TP) assessed by color duplex sonography (CDS) for determination of therapeutic relevant hypoxia. As a standard for measuring tissue oxygenation in human tumors, the invasive, computerized polarographic needle electrode system (pO(2) histography) was used for comparing the different non invasive measurements.Methods: Until now a total of 38 Patients with malignancies of the head and neck were examined. Tumor tissue pO(2) was measured using a pO(2)-histograph. The needle electrode was placed CTcontrolled in the tumor without general or local anesthesia. To assess the biological and clinical relevance of oxygenation measurement, the relative frequency of pO(2) readings, with values