Imported Lassa fever in Germany:: Surveillance and management of contact persons
Imported Lassa fever in Germany:: Surveillance and management of contact persons
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DOI：
10.1086/374853
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发表时间：
2003-05-15
影响因子：
11.8
通讯作者：
Günther, S
中科院分区：
文献类型：
--
作者：
Haas, WH;Breuer, T;Günther, S
本研究旨在评估拉沙热传入欧洲后二次传播的风险。共有 232 名感染者被确诊为输入德国的拉沙热病例。确定了 157 人（68%）的暴露水平，并对 149 人（64%）进行了血清学检测。 157 人中，有 30 人（19%）报告存在高风险或密切接触。未观察到有症状的继发感染。然而，在患病第 9 天对指示患者进行检查的医生处获得的血清样本中检测到了拉沙病毒特异性免疫球蛋白 G 抗体。医生接受了利巴韦林预防治疗，没有出现拉沙热症状。根据这些数据，接触者被归类为可能存在继发感染。该研究表明，即使有高风险暴露，在有症状的拉沙热的初始阶段传播风险也较低。随着疾病的进展和病毒载量的增加，风险可能会增加。
This study sought to assess the risk of secondary transmission after import of Lassa fever into Europe. A total of 232 persons exposed to a case of Lassa fever imported into Germany were identified. The level of exposure was determined for 157 persons (68%), and 149 (64%) were tested serologically. High-risk or close contact was reported by 30 (19%) of 157 persons. No symptomatic secondary infections were observed. However, Lassa virus-specific immunoglobulin G antibodies were detected in a serum sample obtained from a physician who examined the index patient on day 9 of illness. The physician received ribavirin prophylaxis and did not develop symptoms of Lassa fever. On the basis of these data, the contact was classified as having a probable secondary infection. The study indicates a low risk of transmission during the initial phase of symptomatic Lassa fever, even with high-risk exposures. The risk may increase with progression of disease and increasing virus load.