Proton NMR imaging in experimental ischemic infarction.
Proton NMR imaging in experimental ischemic infarction.
复制标题
实验性缺血性梗塞的质子核磁共振成像。
作者：
F. Buonanno;I. Pykett;T. Brady;J. Vielma;C. Burt;M. Goldman;W. Hinshaw;G. Pohost;J. Kistler
质子核磁共振（NMR）图像描绘了由弛豫时间T1和T2修改的移动的质子的分布和浓度。使用稳态自由旋进（SSFP）技术，连续冠状面图像获得随时间推移在实验室动物与实验性缺血性梗死。颈动脉结扎后2小时影像学改变明显，与病理学观察到的缺血性梗死区域相对应。在实验性中风的SSFP图像对比反转恢复核磁共振图像在一个说明性的患者建立脑梗死。散装T1和T2测量在体外三组沙鼠：正常，那些与临床证据的梗死，和那些临床正常颈动脉结扎后。与对侧半球（T1 = 1.28 +/-0.05秒，T2 = 58.7 +/-3.9毫秒）或其他两组相比，切除的半球显著延长了T1和T2（分别为1.47 +/-0.12秒，76.0 +/-9.0毫秒）。这些数据表明，核磁共振参数的变化发生，并可以检测到核磁共振成像早在颈动脉结扎后两个小时。
Proton nuclear magnetic resonance (NMR) images depict the distribution and concentration of mobile protons modified by the relaxation times T1 and T2. Using the steady-state-free-precession (SSFP) technique, serial coronal images were obtained sequentially over time in laboratory animals with experimental ischemic infarction. Image changes were evident as early as 2 hours after carotid artery ligation, and corresponded to areas of ischemic infarction noted pathologically. Resulting SSFP images in experimental stroke are contrasted to inversion-recovery NMR images in an illustrative patient with established cerebral infarction. Bulk T1 and T2 measurements were made in vitro in three groups of gerbils: normal, those with clinical evidence of infarction, and those clinically normal after carotid ligature. Infarcted hemispheres had significantly prolonged T1 and T2 (1.47 +/− .12 sec, 76.0 +/− 9.0 msec, respectively) when compared to the contralateral hemisphere (T1 = 1.28 +/− .05 sec, T2 = 58.7 +/− 3.9 msec) or to the other two groups. These data suggest that changes in NMR parameters occur and can be detected by NMR imaging as early as two hours after carotid artery ligation.