Global distribution and genetic diversity of Bartonella in bat flies (Hippoboscoidea, Streblidae, Nycteribiidae)
Global distribution and genetic diversity of Bartonella in bat flies (Hippoboscoidea, Streblidae, Nycteribiidae)
复制标题
DOI：
10.1016/j.meegid.2012.06.009
复制
发表时间：
2012-12-01
影响因子：
3.2
通讯作者：
Dittmar, Katharina
中科院分区：
文献类型：
--
作者：
Morse, Solon F.;Olival, Kevin J.;Dittmar, Katharina
最近，越来越多的巴尔通体被确定为广泛的人畜共患疾病的病原体，强调了它们的医学重要性。然而，许多哺乳动物宿主和媒介仍然未知，阻碍了我们对病原体生态学的理解，并模糊了流行病学联系。在全球19种吸血蝙蝠蝇（双翅目）样本中检测到新的巴尔通体基因型。在20种寄主蝙蝠中发现了蝙蝠蝇科、夜蛾科、链蝇科等，提示蝙蝠蝇在携带巴尔通体方面具有重要作用。在目前已知的巴尔通体物种和基因型的背景下，探索了进化关系。系统发育和基因网络分析指出巴尔通体与蝙蝠及其宿主的早期进化关联和随后的辐射。将蝙蝠蝇和蝙蝠的巴尔通体基因型结合在一起的独特进化枝的恢复，支持了先前关于这些苍蝇可能是巴尔通体载体的观点。巴尔通体在一些雌性蝙蝠蝇及其蛹中的存在表明，巴尔通体是在发育阶段垂直传播的。蝙蝠和蝙蝠蝇中巴尔通体的具体功能仍然是一个有争议的话题，但除了致病相互作用外，还需要考虑寄生、互惠或宿主功能。(C) 2012 Elsevier B.V.版权所有
Recently, a growing number Bartonella spp. have been identified as causative agents for a broadening spectrum of zoonotic diseases, emphasizing their medical importance. Many mammalian reservoirs and vectors however are still unknown, hindering our understanding of pathogen ecology and obscuring epidemiological connections.New Bartonella genotypes were detected in a global sampling of 19 species of blood-feeding bat flies (Diptera. Hippoboscoidea, Nycteribiidae, Streblidae) from 20 host bat species, suggesting an important role of bat flies in harboring bartonellae. Evolutionary relationships were explored in the context of currently known Bartonella species and genotypes. Phylogenetic and gene network analyses point to an early evolutionary association and subsequent radiation of bartonellae with bat flies and their hosts. The recovery of unique clades, uniting Bartonella genotypes from bat flies and bats, supports previous ideas of these flies potentially being vectors for Bartonella. Presence of bartonellae in some female bat flies and their pupae suggests vertical transmission across developmental stages. The specific function of bartonellae in bats and bat flies remains a subject of debate, but in addition to pathogenic interactions, parasitic, mutualistic, or reservoir functions need to be considered. (C) 2012 Elsevier B.V. All rights reserved.