Heritability estimates for psychotic symptom dimensions in twins with psychotic disorders.
Heritability estimates for psychotic symptom dimensions in twins with psychotic disorders.
复制标题
患有精神病的双胞胎中精神病症状维度的遗传力估计。
DOI：
10.1002/ajmg.b.31145
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Cardno,AlastairG
中科院分区：
文献类型：
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作者：
Rijsdijk,FrühlingV;Gottesman,IrvingI;McGuffin,Peter;Cardno,AlastairG
精神病症状的因子分析经常产生积极、消极和混乱的维度，但遗传性估计尚未报道。症状维度通常仅在患有精神障碍的个体中测量。在这里，评估通过精神病责任和独立改变效应发挥的影响是有价值的。考虑到这些问题，我们估计了精神病症状维度的遗传力。从伦敦莫兹利双胞胎登记处（1948-1993）确定了 224 对先证者患有精神病的先证者双胞胎（106 对同卵，118 对同性异卵）。根据临床记录和研究访谈评估 DSM-III-R 精神障碍的终生史和精神症状维度，并使用操作标准清单进行评级。使用适用于从临床登记处确定的因果-偶然共同路径模型，通过结构方程模型对遗传力和责任方差的环境成分进行了估计。 DSM-III-R 精神障碍（h2=≥90%，95%CI 68-94%）和紊乱症状维度（h2=≥84%，95%CI 18-93%）具有显着的遗传性。当通过精神病责任发挥作用的影响被设置为零时，无组织维度的遗传力仍然显着，这表明对无组织的一些影响是独立于精神病责任的改变因素。然而，改变因素与通过精神病责任产生的影响的相对程度无法明确确定。据我们所知，这项研究提供了第一个关于紊乱症状维度的实质性遗传性的正式证据，并表明影响精神病个体紊乱的遗传位点在某些情况下与影响精神病本身风险的位点不同。 © 2010 Wiley-Liss, Inc.
Factor analysis of psychotic symptoms frequently results in positive, negative, and disorganized dimensions, but heritability estimates have not yet been reported. Symptom dimensions are usually only measured in individuals with psychotic disorders. Here, it is valuable to assess influences acting via liability to psychosis and independent modifying effects. We estimated heritability for psychotic symptom dimensions, taking account of these issues. Two‐hundred‐and‐twenty‐four probandwise twin pairs (106 monozygotic, 118 same‐sex dizygotic), where probands had psychoses, were ascertained from the Maudsley Twin Register in London (1948–1993). Lifetime history of DSM‐III‐R psychotic disorder and psychotic symptom dimensions was assessed from clinical records and research interviews and rated using the Operational Criteria Checklist. Estimates of heritability and environmental components of variance in liability were made with structural equation modeling using a causal‐contingent common pathway model adapted for ascertainment from a clinical register. Significant heritability was found for DSM‐III‐R psychotic disorder (h2= 90%, 95%CI 68–94%) and the disorganized symptom dimension (h2= 84%, 95%CI 18–93%). The heritability for the disorganized dimension remained significant when influences acting through liability to psychosis were set to zero, suggesting that some influences on disorganization are modifying factors independent of psychosis liability. However, the relative extent of modifying factors versus influences acting through psychosis liability could not be clearly determined. To our knowledge, this study provides the first formal evidence of substantive heritability for the disorganized symptom dimension, and suggests that genetic loci influencing disorganization in individuals with psychoses are in some cases different from loci that influence risk of psychotic disorders themselves. © 2010 Wiley‐Liss, Inc.