Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea
Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea
复制标题
DOI：
10.1161/01.cir.100.23.2332
复制
发表时间：
1999-12-07
期刊：
影响因子：
37.8
通讯作者：
Somers, VK
中科院分区：
文献类型：
--
作者：
Narkiewicz, K;Kato, M;Somers, VK
阻塞性睡眠呼吸暂停（OSA）患者有高水平的肌肉交感神经活动（MSNA）。我们测试的假设，长期持续气道正压通气（CPAP）治疗将减少MSNA在OSA patients.Methods和Results-We测量血压，心率，和MSNA在II正常血压，否则健康的OSA患者谁与CPAP治疗，测量结果在基线和CPAP治疗后1个月，6个月，1年。这些测量结果与9例未接受CPAP治疗1年的其他健康OSA患者的测量结果进行了比较。在未治疗和治疗的患者中，血压和心率不随时间变化。在重复测量期间，未处理组的MSNA相似。相比之下，在接受CPAP治疗的患者中，MSNA随着时间的推移而显著降低。CPAP治疗6个月和1年后，这种下降是明显的（P = 0.02）。结论CPAP治疗减少了OSA患者的肌肉交感神经交通。CPAP的这种效果只有在治疗持续时间延长后才明显。
Background-Patients with obstructive sleep apnea (OSA) have high levels of muscle sympathetic nerve activity (MSNA). We tested the hypothesis that long-term continuous positive airway pressure (CPAP) treatment will decrease MSNA in OSA patients.Methods and Results-We measured blood pressure, heart rate, and MSNA in II normotensive, otherwise healthy patients with OSA who were treated with CPAP, The measurements were obtained at baseline and after 1 month, 6 months, and 1 year of CPAP treatment. These measurements were compared with these recorded in 9 otherwise healthy OSA patients who were not treated with CPAP for 1 year. Tn both untreated and treated patients, blood pressure and heart rate did not change over time. MSNA was similar during repeated measurements in the untreated group. By contrast, MSNA decreased significantly over time in patients treated with CPAP. This decrease was evident after both 6 months and 1 year of CPAP treatment (P = 0.02 for both).Conclusions-CPAP treatment decreases muscle sympathetic traffic in patients with OSA. This effect of CPAP is evident only after an extended duration of therapy.