On the road to tolerance — Generation and migration of gut regulatory T cells
On the road to tolerance — Generation and migration of gut regulatory T cells
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DOI：
10.1002/eji.201243154
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发表时间：
2013-06
影响因子：
5.4
通讯作者：
O. Pabst;G. Bernhardt
中科院分区：
文献类型：
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作者：
O. Pabst;G. Bernhardt
肠道免疫系统有力地支持诱导Treg（iTreg）细胞的产生。在肠淋巴隔室内，iTreg细胞接收归巢线索，其将这些细胞引导至肠固有层，在那里它们扩增并局部抑制免疫应答。然而，iTreg细胞只是硬币的一面，其另一面包括在胸腺中产生的天然Treg（nTreg）细胞。与iTreg细胞协同作用的nTreg细胞也获得多种归巢受体模式。因此，iTreg和nTreg细胞可以进入肠道和引流淋巴结，以协同确保肠道内稳态。
The intestinal immune system potently supports the generation of induced Treg (iTreg) cells. Within intestinal lymphoid compartments iTreg cells receive homing cues, which direct these cells to the gut lamina propria where they expand and locally suppress immune responses. Yet iTreg cells are but one side of a coin, the other side of which comprises natural Treg (nTreg) cells generated in the thymus. nTreg cells, which act in concert with iTreg cells, also acquire a diversified pattern of homing receptors. Thus iTreg and nTreg cells can enter the gut, and draining lymph nodes to cooperatively ensure intestinal homeostasis.