Abnormal serum alanine aminotransferase levels are associated with impaired insulin sensitivity in young women with polycystic ovary syndrome
Abnormal serum alanine aminotransferase levels are associated with impaired insulin sensitivity in young women with polycystic ovary syndrome
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DOI：
10.1007/bf03345743
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发表时间：
2009-09-01
影响因子：
5.4
通讯作者：
Moghetti, P.
中科院分区：
文献类型：
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作者：
Targher, G.;Solagna, E.;Moghetti, P.
背景与目的：非酒精性脂肪性肝病(NAFLD)和多囊卵巢综合征(PCOS)均与胰岛素抵抗有关。我们评估了非酒精性脂肪肝是否与多囊卵巢综合征患者的胰岛素敏感性受损有关，而不受年龄和肥胖程度的影响。对象和方法：我们招募了14名患有NAFLD的PCOS年轻女性，14名单独患有PCOS的女性和14名健康对照，他们的年龄、体重指数和总体脂(通过生物阻抗分析仪)都匹配。非酒精性脂肪肝是在排除其他继发性肝病原因(酒精、病毒和药物)后，以血清丙氨酸氨基转移酶(ALT)浓度异常(定义为ALT>；19U/L)的替代指标诊断出来的。正常血糖高胰岛素钳夹法测定胰岛素敏感性。结果：胰岛素敏感性明显降低(P<0.05)。
Background and aim: Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) are both associated with insulin resistance. We assessed whether NAFLD is associated with impaired insulin sensitivity in PCOS women independently of age and total adiposity. Subjects and methods: We enrolled 14 young PCOS women with NAFLD, 14 women with PCOS alone and 14 healthy controls, who were matched for age, body mass index, and total body fat (by bio-impedance analyzer). NAFLD was diagnosed by the surrogate measure of abnormal serum alanine anninotransferase (ALT) concentrations (defined as ALT>19 U/l) after excluding other secondary causes of liver disease (alcohol, virus, and medications). Insulin sensitivity was measured by euglycemic hyperinsulinemic clamp. Results: Insulin sensitivity was markedly decreased (p