Cobalt-catalyzed asymmetric hydrogenation of ketones: A remarkable additive effect on enantioselectivity
Cobalt-catalyzed asymmetric hydrogenation of ketones: A remarkable additive effect on enantioselectivity
复制标题
钴催化的酮的不对称氢化：对对映选择性的显着加和效应
DOI：
10.1016/j.cclet.2020.09.011
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发表时间：
2021-04-21
影响因子：
9.1
通讯作者：
Tang, Weijun
中科院分区：
文献类型：
--
作者：
Du, Tian;Wang, Biwen;Tang, Weijun
手性钴钳配合物，当与非手性富电子单膦配体结合时，催化广泛的芳基酮的有效不对称氢化，提供具有高产率和中等至优异的对映选择性的手性醇（29个实例，高达93%ee）。值得注意的是，非手性单膦配体对反应的对映选择性显示出显著的影响。(C)2020中国化学会、中国医学科学院药物研究所。Elsevier B.V.出版，保留所有权利。
A chiral cobalt pincer complex, when combined with an achiral electron-rich mono-phosphine ligand, catalyzes efficient asymmetric hydrogenation of a wide range of aryl ketones, affording chiral alcohols with high yields and moderate to excellent enantioselectivities (29 examples, up to 93% ee). Notably, the achiral mono-phosphine ligand shows a remarkable effect on the enantioselectivity of the reaction. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.