Distribution of nanoparticle depositions after a single breathing in a murine pulmonary acinus model
Distribution of nanoparticle depositions after a single breathing in a murine pulmonary acinus model
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DOI：
10.1016/j.ijheatmasstransfer.2016.12.057
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发表时间：
2017-05
影响因子：
5.2
通讯作者：
T. Sera;Ryosuke Higashi;H. Naito;Takeshi Matsumoto;Masao Tanaka
中科院分区：
文献类型：
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作者：
T. Sera;Ryosuke Higashi;H. Naito;Takeshi Matsumoto;Masao Tanaka
我们使用计算流体动力学定量研究了肺腺泡中纳米颗粒沉积（密度：1.0 g/cm 3，直径：0.1-1.0 μm）。我们假设腺泡流动是由腺泡模型的膨胀和收缩引起的，其体积随时间呈正弦变化作为边界条件。我们基于哺乳动物肺的复杂腺泡模型和体积变化，并基于三维减薄评估通过腺泡生成的颗粒沉积的分布。进气道和末端肺泡处的最大雷诺数分别为0.191和1.93 × 10−3。在仅有重力的情况下，除了0.1和0.2 μm的颗粒外，颗粒沉积受到强烈影响，0.8和1.0 μm的颗粒由于充气开始后的沉积而沉积在入口周围。我们发现，0.1- 0.4-μm的颗粒沉积在远端肺泡，尽管终末速度很小，但重力和布朗力都会增强沉积。特别是对于0.1-和0.2-μm颗粒，颗粒沉积在整个腺泡中。一次呼吸后，每个腺泡节段的最大沉积分数达到1.2%，并且在中间世代和末端肺泡中较高。
We quantitatively investigated nanoparticle deposition (density: 1.0 g/cm3, diameter: 0.1–1.0 μm) in a pulmonary acinus using computational fluid dynamics. We assumed that acinar flow was induced by the expansion and contraction of the acinar model, with the volume changing sinusoidally with time as the boundary condition. We based the complicated acinar model and volume change on a mammalian lung, and evaluated the distribution of particle depositions through acinar generation based on three dimensional thinning. The maximum Reynolds numbers at the inlet and terminal alveoli were 0.191 and 1.93 × 10−3, respectively. With only gravitational force, particle deposition was strongly affected, except for the 0.1- and 0.2-μm particles, and the 0.8- and 1.0-μm particles were deposited around the inlet due to sedimentation after the beginning of inflation. We found that the 0.1- to 0.4-μm particles were deposited at the distal alveoli and that the deposition was enhanced by both the gravitational and Brownian forces, despite the small terminal velocity. For the 0.1- and 0.2-μm particles in particular, the particles were deposited throughout the acinus. The maximum deposition fraction of each acinar segment reached 1.2% after a single breath, and was higher in the middle generations and at the terminal alveoli.