Serum osteocalcin levels in hyperthyroidism before and after antithyroid therapy
Serum osteocalcin levels in hyperthyroidism before and after antithyroid therapy
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DOI：
10.1620/tjem.203.183
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发表时间：
2004-07-01
影响因子：
2.2
通讯作者：
Erciyas, F
中科院分区：
文献类型：
--
作者：
Barsal, G;Taneli, F;Erciyas, F
甲状腺功能亢进症的特征是骨转换加速，这是由于甲状腺激素增加直接刺激骨细胞引起的。本研究旨在探讨甲亢期患者在抗甲状腺药物(丙基硫氧嘧啶)治疗前和甲亢期抗甲状腺药物治疗后血清骨钙素水平作为骨形成指标的作用。甲亢患者24例(女18例，男6例)，健康对照组20例(女13例，男7例)。分别于甲亢药物治疗前和抗甲状腺治疗后采血、尿标本，直至甲状腺功能正常。测定血清碱性磷酸酶、骨钙素、钙、磷、游离T3、游离T4、TSH和尿钙/肌酐水平。我们发现，与甲亢状态相比，正常甲状腺状态下的血清骨钙素(p=0.006)、尿钙/肌酐(p=0.004)和血磷(p=0.038)水平显著降低。甲亢患者血清骨形成标记物骨钙素和骨吸收标记物尿钙/肌酐水平较正常甲亢时升高，证实甲亢患者有较高的骨转换。我们的结论是，甲亢患者即使在达到正常甲状腺功能后，仍有较高的骨形成和骨吸收转换率。骨钙素和尿钙/肌酐是甲亢治疗中骨重塑的敏感指标。(C)2004年东北大学医科出版社。
Hyperthyroidism is characterized by accelerated bone turnover, caused from direct stimulation of bone cells by increased thyroid hormones. In this study, we aimed to investigate serum osteocalcin levels as a bone formation marker, before antithyroid (propylthiouracil) therapy at hyperthyroid stage and after antithyroid therapy at euthyroid stage of the patients. Twenty four hyperthyroid patients (18 females, 6 males) and 20 (13 females, 7 males) healthy controls were included into this study. Blood and urine samples were taken before medical treatment at hyperthyroid state, and after the antithyroid therapy until the patients reached the euthyroid state. Serum alkaline phosphatase, osteocalcin, calcium, phosphorus, Free T3, Free T4, TSH and urine calcium/creatinine levels were assessed. We found a significant decrease in serum osteocalcin (p=0.006), urinary calcium/creatinine (p=0.004), and serum phosphorus (p=0.038) levels in euthyroid state in comparison to hyperthyroid state. The increases in serum bone formation marker osteocalcin and bone resorption marker urinary calcium/creatinine levels in hyperthyroid state compared to euthyroid state in our study confirmed that hyperthyroid patients have high bone turnover. We conclude that, hyperthyroid patients has high bone turnover of formation and resorption even after attainment of euthyroidism. Osteocalcin and urine calcium/creatinine are sensitive markers in documenting bone remodeling during treatment of hyperthyroidism. (C) 2004 Tohoku University Medical Press.