Added value of CEA scintigraphy in the detection of recurrence of rectal carcinoma
Added value of CEA scintigraphy in the detection of recurrence of rectal carcinoma
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DOI：
10.1034/j.1600-0455.2000.041006629.x
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发表时间：
2000-11-01
期刊：
影响因子：
1.3
通讯作者：
Jacobsson, H
中科院分区：
文献类型：
--
作者：
Järv, V;Blomqvist, L;Jacobsson, H
目的：探讨免疫显像对直肠癌局部复发（LR）的诊断价值，并与CT和/或MR显像进行比较。材料和方法。回顾性分析了46例疑似直肠癌LR的患者。将所有患者的癌胚抗原（CEA）闪烁成像结果与CT和/或MR进行比较，并与手术和形态学（31例）、活检（7例）和随访（8例）的数据进行比较。结果：CEA显像不能与CT和/或MR互补检测LR。CEA显像诊断LR有2例假阳性，14例假阴性。在27例已证实有转移的患者中，仅7例发现远处转移，包括转移淋巴结。CT/MR显示27例患者中有21例转移灶。CEA闪烁显像检测LR和远处转移的准确性和敏感性低于CT和/或MR。然而，CEA闪烁显像似乎具有高特异性，因此可以用于临床怀疑LR但CT/MR检查阴性的患者。现有的诊断方法在区分直肠癌的良性、治疗后变化和LR以及恶性疾病的分期方面存在局限性。
Purpose: To explore the diagnostic value of immunoscintigraphy compared to CT and/or MR imaging in the diagnosis of local recurrence (LR) of rectal cancer.Material and Methods. Forty-six patients suspected of having LR of rectal cancer were retrospectively studied. Carcinoembryonic antigen (CEA) scintigraphy findings were compared to CT and/or MR in all patients, and with data from surgery and morphology (31 patients), biopsy (7 cases) and follow-up (8 patients).Results: CEA scintigraphy was not complementary to CT and/or MR in the detection of LR. Two false-positive and 14 false-negative diagnoses of LR occurred with CEA scintigraphy. Distant metastases including metastatic lymph nodes were found by this method in only 7 of 27 patients with proven metastases. CT/MR were able to demonstrate these metastases in 21 of 27 patients.Conclusion. Accuracy and sensitivity of CEA scintigraphy in the detection of LR and distant metastases is lower than that of CT and/or MR. However, CEA scintigraphy seems to have a high specificity and could therefore be used in patients with a strong clinical suspicion of LR but negative CT/MR investigations. Available diagnostic methods have limitations in differentiating between benign, post-treatment changes and LR of rectal cancer and in staging of malignant disease.