Orchestrating the network of molecular pathways affecting aging: Role of nonselective autophagy and mitophagy
Orchestrating the network of molecular pathways affecting aging: Role of nonselective autophagy and mitophagy
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DOI：
10.1016/j.mad.2016.01.003
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发表时间：
2016-01-01
影响因子：
5.3
通讯作者：
Osiewacz, Heinz D.
中科院分区：
文献类型：
--
作者：
Knuppertz, Laura;Osiewacz, Heinz D.
自噬是最为人所知的一种机制，涉及在营养饥饿期间生物分子的细胞再循环。最近，自噬的另一个功能出现了：选择性降解功能受损或过剩的蛋白质，细胞器和入侵的细菌。有了这个功能，自噬被整合到参与分子和细胞质量控制的途径网络中，对发育和衰老产生关键影响。自噬机制的损伤导致加速衰老和疾病的发展。在这里，我们专注于非选择性自噬和线粒体自噬，线粒体的选择性自噬降解，对生物系统的衰老和寿命的作用。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Autophagy is best known as a mechanism involved in cellular recycling of biomolecules during periods of nutritional starvation. More recently, an additional function of autophagy emerged: the selective degradation of functionally impaired or surplus proteins, organelles and invading bacteria. With this function autophagy is integrated in a network of pathways involved in molecular and cellular quality control with a key impact on development and aging. Impairments in the autophagic machinery lead to accelerated aging and the development of diseases. Here we focus on the role of nonselective autophagy and mitophagy, the selective autophagic degradation of mitochondria, on aging and lifespan of biological systems. (C) 2016 Elsevier Ireland Ltd. All rights reserved.