Caveats associated with the use of human cervical tissue for HIV and microbicide research.
Caveats associated with the use of human cervical tissue for HIV and microbicide research.
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DOI：
10.1097/qad.0b013e328333acfb
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发表时间：
2010-01-02
期刊：
影响因子：
--
通讯作者：
Schust DJ
中科院分区：
文献类型：
--
作者：
Anderson DJ;Pudney J;Schust DJ
艾滋病毒领域转化性研究的一个关键障碍是对艾滋病毒感染早期事件的基本机制了解不足[1]。研究人员最近开始使用人类宫颈组织外植体进行艾滋病毒传播研究和杀微生物剂临床前测试[2-5]，但几个可能显著影响这些研究结果的变量尚未完全解决。
A key roadblock to translational research in the HIV field is insufficient understanding of the basic mechanisms of the earliest events in the establishment of HIV infection [1]. Researchers have recently begun to use human cervical tissue explants for HIV transmission research and microbicide preclinical testing [2–5], but several variables that can dramatically affect the outcome of these studies have not been fully addressed.