Turtle lung cells produce a melanization-stimulating activity that promotes melanocytic differentiation of avian neural crest cells.
Turtle lung cells produce a melanization-stimulating activity that promotes melanocytic differentiation of avian neural crest cells.
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龟肺细胞产生黑化刺激活性，促进鸟类神经嵴细胞的黑素细胞分化。
DOI：
10.1111/j.1600-0749.1995.tb00650.x
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kwon,BS
中科院分区：
文献类型：
--
作者：
Hou,L;Kwon,BS
我们以前发现海龟胚胎的神经嵴细胞迁移到肺芽中，黑素细胞位于肺中。提示肺对神经嵴细胞向黑素细胞的分化有促进作用。我们已经建立了肺细胞系，以便于分析神经嵴细胞与黑素细胞发育中环境的相互作用。发现一种细胞系TLC-2产生推定的促黑素化活性（MSA），其促进禽类神经嵴细胞的体外黑素细胞分化。TLC-2衍生的MSA不同于碱性成纤维细胞生长因子（bFGF）、α-黑素细胞刺激激素（α-MSH）和钢因子（SLF）。其分子量估计在150 kD范围内。我们的研究结果表明，MSA可能是一个新的因素行使积极控制黑素细胞分化。
We found previously that neural crest cells in turtle embryos migrated into the lung buds and melanocytes were located in the lungs. The finding suggested to us that the lungs provide a stimulatory factor(s) to the differentiation of neural crest cells into melanocytes. We have established lung cell lines to facilitate analysis of the interactions of neural crest cells with the environment in melanocyte development. One cell line, TLC‐2, was found to produce a putative melanization‐stimulating activity (MSA), which promoted the melanocyte differentiation in vitro of avian neural crest cells. The TLC‐2‐derived MSA was different from that of basic fibroblast growth factor (bFGF), α‐melanocyte stimulating hormone (α‐MSH), and steel factor (SLF). Its molecular weight was estimated to be within the range of 150 kD. Our findings suggest that MSA may be a novel factor exercising a positive control over melanocyte differentiation.