The mouse Gene Expression Database (GXD): 2017 update
The mouse Gene Expression Database (GXD): 2017 update
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DOI：
10.1093/nar/gkw1073
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发表时间：
2017-01-04
影响因子：
14.9
通讯作者：
Ringwald, Martin
中科院分区：
文献类型：
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作者：
Finger, Jacqueline H.;Smith, Constance M.;Ringwald, Martin
基因表达数据库(GXD；www.informatics.jax.org/pression.shtml)是一个广泛和精心策划的关于小鼠发育表达信息的社区资源。通过科学文献的整理和与大型表达项目的合作，GXD收集并整合了RNA原位杂交、免疫组织化学、RT-PCR、Northern印迹和Western印迹实验的数据。来自野生型和突变小鼠的表达数据都包括在内。表达数据与小鼠基因组信息学(MGI)中的遗传和表型数据相结合，并可供多种类型的数据库搜索访问。目前，GXD包含了超过150万个表达结果和超过30万张图片，所有这些都用详细和标准化的元数据进行了标注。自我们2014年的上一份报告以来，我们增加了大量数据，我们增强了数据和数据库基础设施，我们实施了许多新的搜索和显示功能。界面增强包括：新的老鼠发育解剖学浏览器；按发育阶段和按组织按基因的交互式矩阵视图；筛选和排序表达数据摘要的能力；批量搜索实用程序；基于基因的表达概述；以及到其他物种表达数据的链接。引言
The Gene Expression Database (GXD; www.informatics.jax.org/expression.shtml) is an extensive and well-curated community resource of mouse developmental expression information. Through curation of the scientific literature and by collaborations with large-scale expression projects, GXD collects and integrates data from RNA in situ hybridization, immunohistochemistry, RT-PCR, northern blot and western blot experiments. Expression data from both wild-type and mutant mice are included. The expression data are combined with genetic and phenotypic data in Mouse Genome Informatics (MGI) and made readily accessible to many types of database searches. At present, GXD includes over 1.5 million expression results and more than 300 000 images, all annotated with detailed and standardized metadata. Since our last report in 2014, we have added a large amount of data, we have enhanced data and database infrastructure, and we have implemented many new search and display features. Interface enhancements include: a new Mouse Developmental Anatomy Browser; interactive tissue-by- developmental stage and tissue-by- gene matrix views; capabilities to filter and sort expression data summaries; a batch search utility; gene-based expression overviews; and links to expression data from other species. INTRODUCTION