Mechanisms of Cisplatin nephrotoxicity.
Mechanisms of Cisplatin nephrotoxicity.
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DOI：
10.3390/toxins2112490
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发表时间：
2010-11
期刊：
影响因子：
4.2
通讯作者：
Reeves WB
中科院分区：
文献类型：
--
作者：
Miller RP;Tadagavadi RK;Ramesh G;Reeves WB
Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo. This review summarizes recent advances in our understanding of cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention.
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