INCIDENCE AND RISK-FACTORS ASSOCIATED WITH ABNORMAL POSTPARTUM GLUCOSE-TOLERANCE IN WOMEN WITH GESTATIONAL DIABETES
INCIDENCE AND RISK-FACTORS ASSOCIATED WITH ABNORMAL POSTPARTUM GLUCOSE-TOLERANCE IN WOMEN WITH GESTATIONAL DIABETES
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DOI：
10.1016/0002-9378(91)90438-w
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发表时间：
1991-10-01
影响因子：
9.8
通讯作者：
AMINI, SB
中科院分区：
文献类型：
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作者：
CATALANO, PM;VARGO, KM;AMINI, SB
为了确定妊娠期糖尿病妇女产后糖耐量异常的发生率及相关危险因素，103例妊娠期糖尿病患者在分娩后6 +/- 2周（平均+/- SD）进行了2小时75 gm口服糖耐量试验。22%（23/103）的结果异常：3例显示明显的糖尿病，4例显示糖耐量受损，16例无诊断性。异常组妊娠、孕前体重、体重指数、分娩体重、诊断时胎龄、妊娠期空腹及口服糖耐量试验时2、3小时血糖水平、妊娠期胰岛素治疗需求、新生儿体重> 4000 gm与正常组比较差异均有统计学意义。发现妊娠糖尿病诊断时空腹血糖水平升高（p = 0.0001）和胎龄较早（p = 0.013）最能预测产后糖耐量试验结果异常。这些结果支持了产后口服糖耐量测试对妊娠糖尿病妇女的重要性。
To determine the incidence and risk factors associated with an abnormal postpartum glucose tolerance in women with gestational diabetes, 103 patients with gestational diabetes had a 2-hour, 75 gm oral glucose tolerance test 6 +/- 2 weeks (mean +/- SD) after delivery. Twenty-two percent (23/103) of results were abnormal: Three showed frank diabetes, four showed impaired glucose tolerance, and 16 were nondiagnostic. There was a significant difference in gravidity, pregravid weight and body mass index, delivery weight, gestational age at diagnosis, fasting and 2- and 3-hour glucose level at the time of the oral glucose tolerance test during pregnancy, need for insulin therapy during gestation, and neonatal weight > 4000 gm in the abnormal group as compared with the normal group. Elevated fasting glucose level (p = 0.0001) and earlier gestational age at time of diagnosis of gestational diabetes (p = 0.013) were found to be most predictive of an abnormal postpartum glucose tolerance test result. These results support the importance of postpartum oral glucose tolerance testing in women with gestational diabetes.