Prefrontal cortical regulation of drug seeking in animal models of drug relapse.
Prefrontal cortical regulation of drug seeking in animal models of drug relapse.
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DOI：
10.1007/7854_2009_19
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发表时间：
2010
影响因子：
--
通讯作者：
Fuchs, Rita A
中科院分区：
文献类型：
--
作者：
Lasseter, Heather C;Xie, Xiaohu;Ramirez, Donna R;Fuchs, Rita A
前额叶皮质功能障碍被认为是慢性吸毒者表现出的适应不良行为的基础，最明显的是复发的高倾向，严重阻碍了药物成瘾的成功治疗。在药物复吸的动物模型中，暴露于药物相关刺激、少量药物和急性应激源通过批判性地参与前额叶皮质而有力地恢复药物寻求，其中前扣带、前边缘、边缘下和眶额亚区对药物寻求做出了独特的贡献。因此，从成瘾治疗的角度来看，有必要充分阐明前额叶皮层在药物复吸中的作用。
Prefrontal cortical dysfunction is thought to underlie maladaptive behaviors displayed by chronic drug users, most notably the high propensity for relapse that severely impedes successful treatment of drug addiction. In animal models of drug relapse, exposure to drug-associated stimuli, small amounts of drug, and acute stressors powerfully reinstate drug seeking by critically engaging the prefrontal cortex, with the anterior cingulate, prelimbic, infralimbic, and orbitofrontal subregions making distinct contributions to drug seeking. Hence, from an addiction treatment perspective, it is necessary to fully explicate the involvement of the prefrontal cortex in drug relapse.