Limited Regeneration of Adult Salivary Glands after Severe Injury Involves Cellular Plasticity.
Limited Regeneration of Adult Salivary Glands after Severe Injury Involves Cellular Plasticity.
复制标题
严重损伤后成人唾液腺的有限再生涉及细胞可塑性。
DOI：
10.1016/j.celrep.2018.07.016
复制
发表时间：
2018
期刊：
影响因子：
8.8
通讯作者：
Ovitt,CatherineE
中科院分区：
文献类型：
--
作者：
Weng,Pei-Lun;Aure,MaritH;Maruyama,Takamitsu;Ovitt,CatherineE
在成人唾液腺中，替代和再生腺泡细胞的起源仍不清楚。虽然许多报告描述了成人唾液腺干细胞的鉴定，我们已经表明，分化的腺泡细胞可以保持和再生，通过自我复制。在这里，我们使用遗传小鼠模型，以进一步研究腺泡细胞的更换和再生过程中的稳态和损伤后。在正常情况下或导管结扎后，导管和腺泡细胞的替换通过谱系限制的祖细胞发生。相比之下，照射后，在vivolineage跟踪显示，腺泡，以及导管，细胞有助于腺泡细胞再生，揭示了细胞可塑性参与唾液腺修复。我们的研究结果还表明，即使在辐射损伤后，一些细胞群具有恢复唾液腺功能的再生潜力。
In the adult salivary glands, the origin of replacement and regenerated acinar cells remains unclear. Although many reports describe the identification of stem cells in adult salivary glands, we have shown that differentiated acinar cells can be maintained and regenerated through self-duplication. Here, we have used genetic mouse models to further investigate acinar cell replacement and regeneration during homeostasis and after injury. Under normal conditions or after duct ligation, replacement of duct and acinar cells occurs through lineage-restricted progenitors. In contrast, after irradiation,in vivolineage tracing shows that acinar, as well as duct, cells contribute to acinar cell regeneration, revealing that cellular plasticity is involved in salivary gland repair. Our results also indicate that even after radiation damage, several cell populations have regenerative potential for restoring salivary gland function.