Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria
Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria
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DOI：
10.1016/j.neurobiolaging.2008.05.004
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发表时间：
2010-03-01
影响因子：
4.2
通讯作者：
Weiner, M. W.
中科院分区：
文献类型：
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作者：
Chao, L. L.;Mueller, S. G.;Weiner, M. W.
我们试图确定患有认知障碍但不符合MCI标准的老年人的大脑是否存在结构和代谢变化（即，preMCI）。我们比较了临床痴呆评分（CDR）为0.5，但不符合MCI标准的个体的局部脑叶灰质（GM）和内侧颞叶结构（包括海马、内嗅皮层（ERC）、梭状回和海马旁回）的体积，以及后扣带回的代谢物比率（轻度认知障碍前期，N = 17）、轻度认知障碍患者（轻度认知障碍，N = 13）和认知正常对照组（N = 18）。对照组的ERC、梭形和额叶灰质体积比preMCI和MCI受试者更多，海马旁体积和后扣带回N-乙酰天冬氨酸（NAA）/肌肌醇（mI）比MCI受试者更多。MCI和preMCI受试者在这些指标上没有显著差异。这些研究结果表明，老年人的大脑中存在神经退行性变化，这些老年人的认知主诉严重到足以符合CDR = 0.5，但在正式的神经心理学测试中没有表现出缺陷。这些结果进一步支持了这一假设，即通过使用CDR可以促进对患有非常轻度阿尔茨海默病（AD）的个体的检测，CDR强调个体内认知随时间的变化，而不是与群体规范进行比较。(C)2008年爱思唯尔公司All rights reserved.
We sought to determine whether there are structural and metabolic changes in the brains of older adults with cognitive complaints yet who do not meet MCI criteria (i.e., preMCI). We compared the volumes of regional lobar gray matter (GM) and medial temporal lobe structures, including the hippocampus, entorhinal cortex (ERC), fusiform and parahippocampal gyri, and metabolite ratios from the posterior cingulate in individuals who had a Clinical Demetia Rating (CDR) of 0.5, but who did not meet MCI criteria (preMCI, N = 17), patients with mild cognitive impairment (MCI, N = 13), and cognitively normal controls (N = 18). Controls had more ERC, fusiform, and frontal gray matter volume than preMCI and MCI subjects and greater parahippocampal volume and more posterior cingulate N-acetylaspartate (NAA)/myoinosotil (mI) than MCI. There were no significant differences between MCI and preMCI subjects on any of these measures. These findings suggest there are neurodegenerative changes in the brains of older adults who have cognitive complaints severe enough to qualify for CDR = 0.5 yet show no deficits on formal neuropsychological testing. The results further support the hypothesis that detection of individuals with very mild forms of Alzheimer's disease (AD) may be facilitated by use of the CDR, which emphasizes changes in cognition over time within individuals rather than comparison with group norms. (C) 2008 Elsevier Inc. All rights reserved.