Realistic simulation of transcranial direct current stimulation via 3-d high-resolution finite element analysis: Effect of tissue anisotropy
Realistic simulation of transcranial direct current stimulation via 3-d high-resolution finite element analysis: Effect of tissue anisotropy
复制标题
通过 3 维高分辨率有限元分析真实模拟经颅直流电刺激：组织各向异性的影响
DOI：
10.1109/iembs.2009.5333686
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Tae
中科院分区：
文献类型：
--
作者：
H. Suh;Sang Hyuk Kim;W. Lee;Tae
最近，经颅直流电刺激（tDCS）作为一种有前途的技术而受到关注，它具有非侵入性和非惊厥性刺激的能力，可以治疗抑郁症等大脑疾病。然而，关于 tDCS 究竟如何影响大脑神经元活动的知识仍然不够。精确分析 tDCS 对大脑的电磁效应需要使用有限元分析 (FEA) 和真实的头部模型，包括白质和颅骨的各向异性。在本文中，我们通过 3D 高分辨率 FEA 模拟了 tDCS，并研究了组织各向异性对 tDCS 的影响。结果表明，颅骨各向异性会产生强烈的分流效应，导致刺激区域发生偏移，而白质各向异性会强烈影响电流流向，改变人脑内部的电流场分布。我们提出的方法和结果应该有助于使用 tDCS 进行更有效的指导和治疗。
Recently, transcranial direct current stimulation (tDCS) is getting an attentions as a promising technique with a capability of noninvasive and nonconvulsive stimulation to treat ill conditions of the brain such as depression. However, knowledge on how exactly tDCS affects the activity of neurons in the brain is still not sufficient. Precise analysis on the electromagnetic effect of tDCS on the brain requires finite element analysis (FEA) with realistic head models including anisotropy of the white matter and the skull. In this paper, we have simulated tDCS via 3-D high-resolution FEA and investigated the effect of tissue anisotropy on tDCS. The results show that the skull anisotropy induces a strong shunting effect, causing a shift of the stimulated areas, and the white matter anisotropy affects strongly the current flow directions, changing the current field distribution inside the human brain. Our presented methodology and results should be useful for more effective guiding and treatment using tDCS.