Prenatal brain malformations following acute ethanol exposure in the rat.
Prenatal brain malformations following acute ethanol exposure in the rat.
复制标题
大鼠急性乙醇暴露后产前脑畸形。
DOI：
10.1111/j.1530-0277.1988.tb01355.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Norton,S
中科院分区：
文献类型：
--
作者：
Kotkoskie,LA;Norton,S
在妊娠第14天和第15天（大脑皮质发育的关键时期），对妊娠第21天的胎仔经口给予几种剂量的乙醇（总剂量为10、15或18 g/kg）后，研究了胎仔的大脑皮质形态。所有剂量的乙醇均与母体体重增加、胎仔体重和胎盘重量减少相关。仅高剂量乙醇（总剂量18 g/kg）引起显著的胎仔皮质变薄。妊娠大鼠急性暴露于乙醇可导致胎仔大脑皮层和海马的剂量依赖性畸形。在妊娠第21天，18 g/kg组包含皮质结构严重紊乱、大脑皮质、软脑膜和脉络丛异位以及畸形疣状状态的胎仔。10 g/kg组胎仔的畸形严重程度较低，如皮质神经元和齿状颗粒细胞层的解体，而15 g/kg组胎仔的畸形严重程度和轻微程度混合。这项研究表明，在大鼠发育的关键时期，急性乙醇暴露可导致类似于人类胎儿和酗酒母亲的新生儿报告的脑畸形。
Morphology of the cerebral cortex was studied in fetuses on gestational Day 21 following oral administration of several doses of ethanol (for total doses of 10,15, or 18 g/kg) to pregnant rats on gestational Days 14 and 15, a critical period for the development of the cerebral cortex. All doses of ethanol were associated with a reduction in maternal weight gain, fetal body weight, and placental weight. Only the high dose of ethanol (total dose 18 g/kg) caused significant fetal cortical thinning. Acute exposure of pregnant rats to ethanol produced dose‐dependent malformations of the cerebral cortex and hippocampus in fetuses. On gestational Day 21, the 18 g/kg group contained fetuses with severely disorganized cortical architecture, heterotopias of the cerebral cortex, pia and choroid plexus, and status verrucosus deformis. Fetuses from the 10 g/kg group had less severe malformations, such as disorganization of layers of cortical neurons and dentate granule cells while fetuses from the 15 g/kg group had a mixture of severe and minor malformations. This study demonstrates that acute ethanol exposure during a critical period of development in rats can result in brain malformations similar to those reported in human fetuses and neonates from alcoholic mothers.