Survivin in apoptosis control and cell cycle regulation in cancer.
Survivin in apoptosis control and cell cycle regulation in cancer.
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发表时间：
2003
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通讯作者：
D. Altieri
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作者：
D. Altieri
逃避细胞凋亡和无法控制的增殖能力可能是所有人类癌症的两个分子特征(1)。Survivin位于细胞凋亡调控和细胞增殖调控的交界处，是最近发现的一种分子，在大多数人类肿瘤组织中表达，但在正常组织中不表达。令人鼓舞的新研究表明，利用Survivin途径进行癌症诊断和治疗是可能的。
Evasion of apoptosis, and the ability to proliferate uncontrollably are two of the molecular traits found perhaps in all human cancers (1). Positioned at the interface between the regulation of apoptosis and the control of cell proliferation, survivin is a recently described molecule that is expressed in most human cancers but not in normal tissues. Encouraging new studies demonstrate that it may be possible to exploit the survivin pathway for cancer diagnosis and therapy.