C-reactive protein is associated with arterial stiffness in apparently healthy individuals
C-reactive protein is associated with arterial stiffness in apparently healthy individuals
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DOI：
10.1161/01.atv.zhq0504.0173
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发表时间：
2004-05-01
影响因子：
8.7
通讯作者：
Wilkinson, IB
中科院分区：
文献类型：
--
作者：
Yasmin;McEniery, CM;Wilkinson, IB
目的-C-反应蛋白(CRP)水平可预测健康人和动脉粥样硬化患者的预后。动脉僵硬也独立地预测各种原因和心血管疾病的死亡率，并可能参与动脉粥样硬化的过程。本研究的目的是探讨僵硬与炎症之间的关系。方法和结果：对427名健康个体进行了脉搏波速度(PWV)和血压的评估。有心血管疾病、糖尿病、高胆固醇血症和服用药物的受试者被排除在外。C反应蛋白与年龄、平均动脉压(MAP)、肱动脉和主动脉PWV、脉压相关。在多元回归模型中，主动脉PWV与年龄、C反应蛋白、男性和MAP独立相关(R-2=0.593；P<；0.001)。此外，C反应蛋白与上臂PWV独立相关。主动脉增大指数与年龄、性别、平均动脉压呈负相关，与心率、身高呈负相关，与C反应蛋白无相关性(R-2=0.794；P<；0.001)。主动脉、颈动脉和臂动脉脉压也与C反应蛋白水平独立相关。结论：在健康个体中，动脉脉压和脉压与炎症水平有关，提示炎症可能参与了动脉硬化。因此，抗炎策略可能有益于降低动脉僵硬，从而降低心血管风险，特别是在动脉过早硬化的患者中。
Objective-C-reactive protein (CRP) levels predict outcome in healthy individuals and patients with atherosclerosis. Arterial stiffness also independently predicts all-cause and cardiovascular mortality and may be involved in the process of atherosclerosis. The aim of this study was to investigate the relationship between stiffness and inflammation in a cohort of healthy individuals.Methods and Results-Pulse wave velocity (PWV) and blood pressure were assessed in 427 individuals. Subjects with cardiovascular disease, diabetes, hypercholesterolemia and those using medication were excluded. CRP correlated with age, mean arterial pressure (MAP), brachial and aortic PWV, and pulse pressures. In multiple regression models, aortic PWV correlated independently with age, CRP, male gender, and MAP (R-2 = 0.593; P < 0.001). CRP was also independently associated with brachial PWV. Aortic augmentation index correlated with age, gender, MAP, and inversely with heart rate and height, but not with CRP (R-2 = 0.794; P < 0.001). Aortic, carotid, and brachial pulse pressures were also independently associated with CRP levels.Conclusion-Aortic and brachial PWV, and pulse pressure, relate to levels of inflammation in healthy individuals, suggesting that inflammation may be involved in arterial stiffening. Anti-inflammatory strategies may, therefore, be of benefit in reducing arterial stiffness and thus cardiovascular risk, especially in patients with premature arterial stiffening.