Cutting edge: CD8 T cells specific for lymphocytic choriomeningitis virus require type IIFN receptor for clonal expansion
Cutting edge: CD8 T cells specific for lymphocytic choriomeningitis virus require type IIFN receptor for clonal expansion
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DOI：
10.4049/jimmunol.176.8.4525
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发表时间：
2006-04-15
影响因子：
4.4
通讯作者：
Vucikuja, S
中科院分区：
文献类型：
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作者：
Aichele, P;Unsoeld, H;Vucikuja, S
在过继转移模型中，使用对淋巴细胞性脉络丛脑膜炎病毒（LCMV）特异性但缺乏I型IFNR的P14 TCR转基因CD 8 T细胞，分析I型IFN信号传导在CD 8 T细胞中的作用。在本研究中，我们证明了严重损害的能力缺乏I型IFNR的P14 T细胞在正常I型IFNR野生型C57 BL/6主机LCMV感染后扩展。相反，用表达LCMV糖蛋白的重组牛痘病毒感染受体小鼠后，P14 T细胞扩增对I型IFNR表达的依赖性大大降低。缺乏I型IFNR表达的P14 T细胞不影响LCMV感染后的细胞分裂，但干扰克隆扩增。因此，直接I型IFN信号传导对于某些病毒感染中的CD 8 T细胞存活是必需的。
The role of type I IFN signaling in CD8 T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR. In the present study, we demonstrate severe impairment in the capacity of P14 T cells lacking type I IFNR to expand in normal type I IFNR wild-type C57BL/6 hosts after LCMV infection. In contrast, following infection of recipient mice with recombinant vaccinia virus expressing LCMV glycoprotein, P14 T cell expansion was considerably less dependent on type I IFNR expression. Lack of type I IFNR expression by P14 T cells did not affect cell division after LCMV infection but interfered with clonal expansion. Thus, direct type I IFN signaling is essential for CD8 T cell survival in certain viral infections.