Role of STAT3 in Pancreatic Cancer: A Target for Therapy
Role of STAT3 in Pancreatic Cancer: A Target for Therapy
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DOI：
10.1007/978-981-10-6728-0_24
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Yu, David S.
中科院分区：
文献类型：
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作者：
Daddacha, Waaqo B.;Koyen, Allyson E.;Yu, David S.
STAT3是信号转导和转录激活因子（STAT）蛋白家族的成员。STAT3信号级联的激活导致几种促增殖和抗凋亡蛋白的转录。STAT3也是免疫系统的有效调节剂，其激活导致免疫应答的抑制。STAT3的失调涉及许多恶性肿瘤的发展和进展，包括胰腺导管腺癌。由于其参与肿瘤发生和逃避免疫反应，STAT3正在成为胰腺癌的潜在治疗靶点，目前正在开发几种治疗方法。
STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.