Serological evidence for long-term Epstein-Barr virus reactivation in children living in a holoendemic malaria region of Kenya.
Serological evidence for long-term Epstein-Barr virus reactivation in children living in a holoendemic malaria region of Kenya.
复制标题
生活在肯尼亚疟疾大流行地区的儿童中长期 Epstein-Barr 病毒重新激活的血清学证据。
DOI：
10.1002/jmv.21485
复制
发表时间：
2009
影响因子：
12.7
通讯作者：
Rochford,Rosemary
中科院分区：
文献类型：
--
作者：
Piriou,Erwan;Kimmel,Rhonda;Chelimo,Kiprotich;Middeldorp,JaapM;Odada,PeterSumba;Ploutz-Snyder,Robert;Moormann,AnnM;Rochford,Rosemary
To study the long term the effects of chronic exposure toP. falciparummalaria on Epstein–Barr virus (EBV) reactivation in children, EBV‐specific antibody levels were measured in a cross‐sectional survey of two groups of Kenyan children with divergent malaria exposure, varying in age from 1 to 14 years. A total of 169 children were analyzed within three age groups (1–4 years, 5–9 years and 10–14 years). Using a Luminex assay, elevated levels of IgG to EBV lytic and latent antigens were observed in children from the holoendemic malaria area; these remained elevated for each age group studied. In comparison, children from the sporadic malaria area had lower levels of EBV‐specific IgG antibodies and these levels declined across age groups. These data suggest that chronic exposure to malaria may lead to long‐term EBV reactivation. J. Med. Virol. 81:1088–1093, 2009. © 2009 Wiley‐Liss, Inc.
