Chromogranin-A and its derived peptides and their pharmacological effects during intestinal inflammation
Chromogranin-A and its derived peptides and their pharmacological effects during intestinal inflammation
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DOI：
10.1016/j.bcp.2018.04.009
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发表时间：
2018-06-01
影响因子：
5.8
通讯作者：
Ghia, Jean-Eric
中科院分区：
文献类型：
--
作者：
Eissa, Nour;Hussein, Hayam;Ghia, Jean-Eric
胃肠道是最大的内分泌器官，产生广泛的活性肽。炎症过程中的粘液变化改变了肠内分泌细胞（EEC）的分布和产物，这些细胞通过介导神经、内分泌和免疫系统之间的通讯，在免疫激活和肠道稳态调节中发挥作用。炎症性肠病（IBD）患者的嗜铬粒蛋白（CHG）-A（CHGA）表达通常会发生改变，CHGA是一种由EEC分泌的主要可溶性蛋白质，其功能是激素原。CHGA产生几种对肠道炎症具有直接或间接作用的生物活性肽。在IBD中，CHGA及其衍生肽与疾病活动相关。在这篇综述中，我们描述了CHGA及其衍生肽的潜在免疫调节作用及其在肠道炎症进展过程中的临床意义。靶向CHGA及其衍生肽可能有利于IBD患者的诊断和临床管理。
The gastrointestinal tract is the largest endocrine organ that produces a broad range of active peptides. Mucosal changes during inflammation alter the distribution and products of enteroendocrine cells (EECs) that play a role in immune activation and regulation of gut homeostasis by mediating communication between the nervous, endocrine and immune systems. Patients with inflammatory bowel disease (IBD) typically have altered expression of chromogranin (CHG)-A (CHGA), a major soluble protein secreted by EECs that functions as a pro hormone. CHGA gives rise to several bioactive peptides that have direct or indirect effects on intestinal inflammation. In IBD, CHGA and its derived peptides are correlated with the disease activity. In this review we describe the potential immunomodulatory roles of CHGA and its derived peptides and their clinical relevance during the progression of intestinal inflammation. Targeting CHGA and its derived peptides could be of benefit for the diagnosis and clinical management of IBD patients.