Dopamine signaling in reward-related behaviors.
Dopamine signaling in reward-related behaviors.
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与奖励相关行为中的多巴胺信号传导。
DOI：
10.3389/fncir.2013.00152
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发表时间：
2013
影响因子：
3.5
通讯作者：
Baik JH
中科院分区：
文献类型：
--
作者：
Baik JH
多巴胺(DA)通过中脑边缘多巴胺能通路调节情绪和动机行为。多巴胺中脑边缘神经传递的改变被发现改变了对与奖赏行为相关的各种环境刺激的行为反应。精神刺激剂、滥用药物和食物等自然奖赏可以导致中脑边缘DA系统的大量突触改变。最近利用光遗传学和DREADDS的研究，以及神经元特异性或电路特异性的遗传操作，提高了我们对奖赏回路中DA信号的理解，并提供了一种识别复杂行为(如药物成瘾和饮食失调)的神经底物的方法。本文综述了多巴胺系统在药物成瘾和食物动机中的作用，并对D1和D2受体在控制奖赏相关行为中的作用进行了综述。
Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to modify behavioral responses to various environmental stimuli associated with reward behaviors. Psychostimulants, drugs of abuse, and natural reward such as food can cause substantial synaptic modifications to the mesolimbic DA system. Recent studies using optogenetics and DREADDs, together with neuron-specific or circuit-specific genetic manipulations have improved our understanding of DA signaling in the reward circuit, and provided a means to identify the neural substrates of complex behaviors such as drug addiction and eating disorders. This review focuses on the role of the DA system in drug addiction and food motivation, with an overview of the role of D1 and D2 receptors in the control of reward-associated behaviors.