The syndrome of congenitally aplastic ovaries with sexual infantilism, high urinary gonadotropins, short stature and other congenital abnormalities; tabular presentation of 25 previously unpublished cases.
The syndrome of congenitally aplastic ovaries with sexual infantilism, high urinary gonadotropins, short stature and other congenital abnormalities; tabular presentation of 25 previously unpublished cases.
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先天性卵巢发育不良综合征，伴有性幼稚症、尿促性腺激素高、身材矮小等先天性异常；
DOI：
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发表时间：
1947
影响因子：
5.8
通讯作者：
M. Goldberg
中科院分区：
文献类型：
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作者：
H. Lisser;L. E. Curtis;R. Escamilla;M. Goldberg
1938年，特纳(7)报告了10例新的综合征，仅限于女性，其特征是性幼稚、身材矮小、颈部带状和肘外翻。这是美国文献中第一篇引起人们对这种综合征的关注的报告，后来发现这种综合征包括先天性再生障碍性卵巢。对这种情况的下一次了解出现在1942年，当时Varney，Kenyon和Koch(8)描述了4名身材矮小、性发育迟缓的女性，她们都排出了异常大量的尿促性腺激素；事实上，她们的滴度与去势或绝经后的女性相当。根据在国外文献中发现的7份零星尸检报告，他们认为卵巢发育不全是该综合征的主要特征之一。同年晚些时候，奥尔布赖特、史密斯和弗雷泽(1)提交了他们自己的11例患者，特别强调了原发性卵巢功能不全，并讨论了它与原发性垂体瘤的鉴别。
IN 1938, Turner (7) reported 10 instances of a new syndrome, confined to females, and characterized by sexual infantilism, short stature, webbing of the neck, and cubitus valgus. This was the first report in the American literature calling attention to the syndrome, which later was found to include congenitally aplastic ovaries. The next contribution to the understanding of this condition appeared in 1942 when Varney, Kenyon, and Koch (8) described 4 short, sexually retarded females, all of whom excreted abnormally large amounts of urinary gonadotropins; indeed their titers equalled those of castrate or postmenopausal women. On the basis of 7 scattered autopsy reports discovered in the foreign literature, they suggested the importance of ovarian aplasia as one of the cardinal characteristics of the syndrome. Later that same year, Albright, Smith, and Fraser (1) submitted 11 patients of their own, particularly stressing the primary ovarian insufficiency and discussing its differentiation from primary pitui...