Silica nanoparticles induce oxidative stress and inflammation of human peripheral blood mononuclear cells
Silica nanoparticles induce oxidative stress and inflammation of human peripheral blood mononuclear cells
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DOI：
10.1007/s12192-014-0502-y
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发表时间：
2014-11-01
影响因子：
3.8
通讯作者：
Lawrence, David A.
中科院分区：
文献类型：
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作者：
Mendoza, Alvaro;Torres-Hernandez, Jose A.;Lawrence, David A.
在本研究中，10-或100-nm的二氧化硅（SiO2）纳米粒子对人外周血单核细胞（PBMC）的影响进行了检查。测定了细胞毒性作用和氧化应激作用，包括谷胱甘肽（GSH）耗竭、蛋白质自由基种类的形成和促炎细胞因子反应。暴露于浓度为50 - 4，000 ppm的10 nm NP的PBMC显示细胞死亡的浓度-反应增加;而对于100 nm NP，PBMC活力在50 - 4，000 ppm时未丧失。
In the present study, the effects of 10- or 100-nm silica oxide (SiO2) NPs on human peripheral blood mononuclear cells (PBMC) were examined. Cytotoxic effects and oxidative stress effects, including glutathione (GSH) depletion, the formation of protein radical species, and proinflammatory cytokine responses, were measured. PBMC exposed to 10-nm NP concentrations from 50 to 4,000 ppm showed concentration-response increases in cell death; whereas, for 100-nm NPs, PBMC viability was not lost at