Fibulin-5 function during tumorigenesis.
Fibulin-5 function during tumorigenesis.
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DOI：
10.1517/14796694.1.1.23
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发表时间：
2005-02-01
期刊：
影响因子：
--
通讯作者：
Schiemann, William P
中科院分区：
文献类型：
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作者：
Albig, Allan R;Schiemann, William P
肿瘤发生是正常细胞进化出逃避和克服通常对其生长和存活的限制的能力的过程。在癌症进展过程中，惰性肿瘤经历一系列遗传和表观遗传事件，最终协调肿瘤转移的发展，这是癌症最致命的方面，也是癌症相关死亡的主要原因。对抗肿瘤转移的治疗必要性继续推动旨在确定这一致命过程的新型调节剂的研究。Fibulin-5是一种新发现的细胞外基质蛋白，对胚胎的正常发育和器官形成有重要作用。纤蛋白-5表达也可能通过其控制细胞增殖、运动性和血管生成发芽而与肿瘤形成的抑制相关。本文综述了fibulin-5的肿瘤抑制活性，并讨论了fibulin-5在对抗人类恶性肿瘤生长和转移方面的潜在用途和靶向作用。
Tumorigenesis is the process by which normal cells evolve the capacity to evade and overcome the constraints normally placed upon their growth and survival. During cancer progression, indolent tumors experience an array of genetic and epigenetic events that ultimately coordinate the development of tumor metastasis, which is the most lethal facet of cancer and the leading cause of cancer-related death. The therapeutic necessity to combat tumor metastasis continues to drive investigations aimed at identifying novel regulators of this deadly process. Fibulin-5 is a newly described extracellular matrix protein that is important for normal embryonic development and organogenesis. Fibulin-5 expression may also be associated with the suppression of tumor formation through its control of cell proliferation, motility and angiogenic sprouting. Here, the tumor suppressing activities of fibulin-5 are reviewed, and the potential use and targeting of fibulin-5 to combat growth and metastasis of human malignancies is discussed.