Gonadal influences on adiposity.
Gonadal influences on adiposity.
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DOI：
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发表时间：
1985
影响因子：
4.9
通讯作者：
G. Wade;J. Gray;T. Bartness
中科院分区：
文献类型：
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作者：
G. Wade;J. Gray;T. Bartness
性腺类固醇影响各种哺乳动物的能量平衡和肥胖。例如，雌二醇通过多种冗余机制来减轻体重和肥胖。类固醇可以直接作用于大脑，减少食物摄入量，刺激自愿锻炼。性激素可以同时作用于非神经外周组织，以改变代谢过程和能量平衡。白色脂肪组织雌激素受体可能介导雌二醇诱导的脂蛋白脂肪酶活性和脂质储存的降低。最后，雌二醇增加能量消耗独立于对自愿运动的任何影响。棕色脂肪组织是雌二醇诱导产热的潜在部位。
Gonadal steroids affect energy balance and adiposity in a variety of mammalian species. For example, estradiol acts via multiple, redundant mechanisms to reduce body weight and adiposity. The steroid can act directly in the brain to decrease food intake and stimulate voluntary exercise. Sex hormones may act concurrently in non-neural peripheral tissues to alter metabolic processes and energy balance. White adipose tissue estrogen receptors may mediate estradiol-induced decreases in lipoprotein lipase activity and lipid storage. Finally, estradiol increases energy expenditure independent of any effects on voluntary exercise. Brown adipose tissue is a potential site for estradiol-induced thermogenesis.