Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses
Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses
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DOI：
10.1099/vir.0.83354-0
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发表时间：
2008-03-01
影响因子：
3.8
通讯作者：
Segales, Joaquim
中科院分区：
文献类型：
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作者：
Kekarainen, Tuija;Montoya, Maria;Segales, Joaquim
猪圆环病毒2型（PCV 2）是引起断奶仔猪多系统衰竭综合征（PMWS）的重要病原。有人认为，PMWS感染的猪免疫抑制，因此，更容易发展的共同感染。在这项研究中，我们阐明了PCV 2下调;在回忆抗原应答过程中的免疫细胞功能。我们发现，PCV 2，而不是非致病性猪圆环病毒1型，诱导单核细胞分泌白细胞介素（IL）-10。值得注意的是，PCV 2诱导的IL-10导致血液外周单核细胞（PBMC）中IL-12的有效抑制。除了通过来自伪狂犬病病毒（PRV）免疫的动物的PBMC合成α和γ干扰素之外，体外活化的PRV也被随后的PCV 2感染抑制。PCV 2阻碍免疫应答发展的能力可能有助于Th 1抑制应答、免疫抑制和合并感染。
Porcine circovirus type 2 (PCV2) is the necessary agent for the occurrence of post-weaning multisystemic wasting syndrome (PMWS) in pigs. It has been suggested that PMWS-affected pigs are immunosuppressed and, therefore, more prone to develop co-infections. In this study, we elucidated that PCV2 downregulates; in vitro the immune cell functions during recall antigen responses. We showed that PCV2, but not the non-pathogenic porcine circovirus type 1, induces interleukin (IL)-10 secretion by monocytic cells. Notably, PCV2-induced IL-10 led to effective repression of IL-12 in blood peripheral mononuclear cells (PBMCs). Besides alpha and gamma interferon synthesis by PBMCs from pseudorabies virus (PRV)-immunized animals, activated in vitro PRV also was repressed by subsequent infection by PCV2. The ability of PCV2 to hamper the development of immune responses may contribute to the Th1 suppressed responses, immune suppression and co-infections.