A Focus on the HIV Care Continuum Through the Healthy Young Men's Cohort Study: Protocol for a Mixed-Methods Study
A Focus on the HIV Care Continuum Through the Healthy Young Men's Cohort Study: Protocol for a Mixed-Methods Study
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DOI：
10.2196/10738
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发表时间：
2019-01-01
影响因子：
1.7
通讯作者：
Belzer, Marvin
中科院分区：
文献类型：
--
作者：
Kipke, Michele D.;Kubicek, Katrina;Belzer, Marvin
背景资料：没有任何群体比男男性行为青年（YMSM）更容易感染艾滋病毒，特别是生活在市中心的黑人或非洲裔美国人（AA）和西班牙裔或拉丁美洲人（L）YMSM，他们每年新感染艾滋病毒的人数最多。尽管暴露前预防（PrEP）、暴露后预防（PEP）和作为预防的治疗对改变流行病的进程有着巨大的希望，但AA/L-YMSM是最不可能接受初级卫生保健和艾滋病毒预防/护理的人群，也是最不可能使用PrEP和PEP的人群。目的：健康青年男性（HYM）队列研究的总体目标是对AA/L-YMSM队列进行纵向研究，以预防新的HIV感染，减少传播，通过注重成功地参与护理，减少与艾滋病毒/艾滋病有关的差距。从这项研究的结果将被用来通知新的干预措施的发展，旨在从事AA/L-YMSM在HIV的预防和护理continua.Methods：纵向研究（基线和随访评估，每6个月共8波的数据收集）正在进行一个新的队列的450高风险AA/L-YMSM在洛杉矶。参与者是使用基于场地和社交媒体的抽样设计招募的。除了自我报告调查外，研究方案还包括收集尿液以评估最近使用非法药物的情况，以及收集血液和直肠/咽喉拭子以检测当前的性传播感染/艾滋病毒感染。还采集了额外的血液/血浆样本（10 mL，4等份和1个颗粒），并储存在HYM队列研究生物储存库中，用于未来研究。通过设计，我们招募了400名HIV阴性参与者和50名HIV阳性（HIV+）参与者。该混合方法研究设计包括在基线和每6个月收集和三角分析定量、定性和生物学指标（即，HIV+参与者中的药物使用、STI/HIV检测和抗逆转录病毒治疗依从性）。HYM队列研究将提供一个平台，（例如，PrEP，直肠杀微生物剂，和PEP）和其他艾滋病毒预防和护理参与干预措施可以开发和评估与AA/L-YMSM.结果：到目前为止，所有参与者在HYM队列研究已招募和基线评估已进行。结论：这项研究的结果将用于为制定新的和/或调整现有的循证艾滋病毒预防干预措施以及旨在使这一人群参与艾滋病毒预防和护理的干预措施提供信息。
Background: No group is at greater risk for acquiring HIV than young men who have sex with men (YMSM), particularly black or African American (AA) and Hispanic or Latino (L) YMSM living in inner cities, who account for the largest number of new HIV infections each year. Although pre-exposure prophylaxis (PrEP), postexposure prophylaxis (PEP), and treatment as prevention hold enormous promise for changing the course of the epidemic, AA/L-YMSM are the least likely population to be receiving primary health care and HIV prevention/care and are the least likely to be using PrEP and PEP.Objective: The overarching aim of the Healthy Young Men's (HYM) cohort study is to conduct longitudinal research with a cohort of AA/L-YMSM to prevent new HIV infections, reduce transmission, and reduce HIV/AIDS-related disparities by focusing on successful engagement in care. Findings from this research will be used to inform the development of new interventions designed to engage AA/L-YMSM in the HIV prevention and care continua.Methods: Longitudinal research (baseline and follow-up assessments every 6 months for a total of 8 waves of data collection) is ongoing with a new cohort of 450 high-risk AA/L-YMSM in Los Angeles. Participants were recruited using a venue-based and social media sampling design. In addition to self-report surveys, the study protocol includes the collection of urine to assess recent use of illicit drugs and the collection of blood and rectal/throat swabs to test for current sexually transmitted infection (STI)/HIV infection. An additional sample of blood/plasma (10 mL for 4 aliquots and 1 pellet) is also collected and stored in the HYM cohort study biorepository for future research. By design, we recruited 400 HIV-negative participants and 50 HIV-positive (HIV+) participants. This mixed-methods study design includes collection and triangulated analysis of quantitative, qualitative, and biological measures (ie, drug use, STI/HIV testing, and adherence to antiretroviral therapy among HIV+ participants) at baseline and every 6 months. The HYM cohort study will provide a platform from which new and emerging biomedical prevention strategies (eg, PrEP, rectal microbicides, and PEP) and other HIV prevention and care engagement interventions can be developed and evaluated with AA/L-YMSM.Results: To date, all participants in the HYM cohort study have been recruited and baseline assessment has been conducted.Conclusions: The findings from this research will be used to inform the development of new and/or adaptation of existing evidence-based HIV prevention interventions and interventions designed to engage this population in the HIV prevention and care continua.