METABOLIC SYNDROME IN THE ELDERLY: AN OVERVIEW OF THE EVIDENCE
METABOLIC SYNDROME IN THE ELDERLY: AN OVERVIEW OF THE EVIDENCE
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DOI：
10.1179/acb.2009.006
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发表时间：
2009-01-01
影响因子：
1.6
通讯作者：
Petrovic, M.
中科院分区：
文献类型：
--
作者：
Denys, K.;Cankurtaran, M.;Petrovic, M.
我们回顾了有关老年人代谢综合征(METS)患病率及其相关因素的文献，并评估了METS对老年人(65岁及以上)预期寿命和合并症的影响。利用PubMed数据库和Cochrane图书馆，我们找到了16项符合条件的研究，其中8项是前瞻性队列研究，7项是横断面研究，1项是病例对照研究。世界卫生组织(WHO)和国家胆固醇教育计划(NCEP)是描述老年人代谢综合征的最流行的定义。根据世界卫生组织的数据，老年人口中代谢综合征的患病率从11%到43%(中位数21%)不等，根据NCEP的数据，从23%到55%(中位数31%)。肥胖和高血压是最普遍的个体因素。在老年人群中，蛋氨酸是心血管(CV)发病率，特别是中风和冠心病(CHD)发病率和死亡率的已被证实的危险因素。预防和治疗甲硫氨酸将有助于预防残疾和促进正常衰老。对老年人群队列的不同研究结果为早期在中年人群中预防METS成分的研究提供了支持。总而言之，来自不同老年研究人群的结果可以说，METS的存在与心血管疾病(CVD)和功能残疾的发展有关，并进一步强调了认识和治疗其个别成分，特别是高血压的重要性。
We reviewed the literature concerning the prevalence and correlates of metabolic syndrome (MetS) in older adults and assessed the impact of MetS with regard to life expectancy and comorbidity in the elderly (aged 65 years and over).Using the PubMed database and the Cochrane Library, we found 16 eligible studies, of which 8 were prospective cohort studies, 7 cross-sectional studies, and 1 a case-controt study.The World Health Organisation (WHO) and National Cholesterol Education Program (NCEP) are the most popular definitions to describe MetS experienced by the elderly. The prevalence of metabolic syndrome in an elderly population varied from 11% to 43% (median 21 %) according to the WHO, and 23% to 55 % (median 31%) according to NCEP. Obesity and hypertension are the most prevalent individual components. MetS in an elderly population is a proven risk factor for cardiovascular (CV) morbidity, especially stroke and coronary heart disease (CHD), and mortality. Preventing and treating MetS would be useful in preventing disability and promoting normal aging. Results from the different studies of elderly population-based cohorts provide support for earlier investigations in middle-aged populations to prevent MetS components.In conclusion, it is possible to say that the results from the different elderly study populations link the presence of the MetS with the development of cardiovascular disease (CVD) and functional disability, and further underscore the importance of recognising and treating its individual components, particularly high blood pressure.