Mechanism of the alcohol cyclic pattern: role of the hypothalamic-pituitary-thyroid axis
Mechanism of the alcohol cyclic pattern: role of the hypothalamic-pituitary-thyroid axis
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DOI：
10.1152/ajpgi.2000.279.1.g118
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发表时间：
2000-07-01
影响因子：
4.5
通讯作者：
French, SW
中科院分区：
文献类型：
--
作者：
Li, J;Nguyen, V;French, SW
以固定速率连续喂食乙醇的大鼠尿酒精水平（UAL）周期的原因尚不清楚。以恒定剂量灌胃乙醇2个月，记录每日体温和UAL。体温与UAL呈反比循环，表明代谢速率可能在循环期间机械地参与乙醇消除速率。为了记录这一点，在循环期间每天监测全身O-2消耗率。O-2消耗率与体温变化呈正相关，与UAL变化呈负相关。由于代谢率对体温变化有反应，因此在UAL周期期间测量甲状腺激素水平。T-4水平与O-2消耗率呈正相关，与UAL呈负相关。在使用丙基硫氧嘧啶治疗的第二个实验中，UAL没有循环，体温下降未能刺激乙醇消除速率的增加。结果，大鼠死于过量。同样，在第三个实验中，使用切断垂体柄的大鼠，UAL无法循环，大鼠死于过量。从这些观察结果可以得出结论，UAL周期依赖于一个完整的下丘脑-垂体-甲状腺轴的反应，乙醇诱导的体温下降，增加乙醇消除率。
The cause of the cycle of urinary alcohol levels (UALs) in rats fed ethanol continually at a fixed rate is unknown. Rats were fed ethanol intragastrically at a constant dose for 2 mo, and daily body temperatures and UALs were recorded. Body temperature cycled inversely to UAL, suggesting that the rate of metabolism could be mechanistically involved in the rate of ethanol elimination during the cycle. To document this, whole body O-2 consumption rate was monitored daily during the cycle. The rate of O-2 consumption correlated positively with the change in body temperature and negatively with the change in UAL. Since the metabolic rate responds to changes in body temperature, thyroid hormone levels were measured during the UAL cycle. T-4 levels correlated positively with the O-2 consumption rate and negatively with the UALs. In a second experiment using propylthiouracil treatment, UALs did not cycle and a fall in body temperature failed to stimulate an increase in the rate of ethanol elimination. Consequently, rats died of overdose. Likewise, in a third experiment using rats with severed pituitary stalks, UALs failed to cycle and rats died of overdose. From these observations it was concluded that the UAL cycle depends on an intact hypothalamic-pituitary-thyroid axis response to the ethanol-induced drop in body temperature by increasing the rate of ethanol elimination.