Novel Metal Nanomaterials to Promote Angiogenesis in Tissue Regeneration.
Novel Metal Nanomaterials to Promote Angiogenesis in Tissue Regeneration.
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DOI：
10.1016/j.engreg.2023.03.008
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发表时间：
2023-09
影响因子：
--
通讯作者：
Yang, Jian
中科院分区：
文献类型：
--
作者：
Yoshida, Yuki G;Yan, Su;Xu, Hui;Yang, Jian
血管生成--从现有血管形成新的血管--在医学研究中引起了极大的关注。已经开发了新的技术来控制促血管生成因子以获得预期的效果。两个重要的研究领域是1)了解参与血管生成的细胞机制和信号通路；2)发现具有促血管生成作用的新的生物材料和纳米材料。本文综述了在再生医学和伤口愈合方面控制血管生成的最新进展。我们专注于新型促血管生成材料，这些材料将推动再生医学领域的发展。具体地说，我们主要关注金属纳米材料。我们还讨论了开发的新技术，以有效地将这些促血管生成的无机分子携带到靶点。我们通过将现有的关于金属纳米材料的知识与仍在改进中的新发展相结合来提供一个全面的概述，以识别新的纳米材料。
Angiogenesis—the formation of new blood vessels from existing blood vessels—has drawn significant attention in medical research. New techniques have been developed to control proangiogenic factors to obtain desired effects. Two important research areas are 1) understanding cellular mechanisms and signaling pathways involved in angiogenesis and 2) discovering new biomaterials and nanomaterials with proangiogenic effects. This paper reviews recent developments in controlling angiogenesis in the context of regenerative medicine and wound healing. We focus on novel proangiogenic materials that will advance the field of regenerative medicine. Specifically, we mainly focus on metal nanomaterials. We also discuss novel technologies developed to carry these proangiogenic inorganic molecules efficiently to target sites. We offer a comprehensive overview by combining existing knowledge regarding metal nanomaterials with novel developments that are still being refined to identify new nanomaterials.