Catecholamines in human saliva
Catecholamines in human saliva
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DOI：
10.1016/s0024-3205(01)01111-0
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发表时间：
2001-05-25
期刊：
影响因子：
6.1
通讯作者：
Ziegler, MG
中科院分区：
文献类型：
--
作者：
Kennedy, B;Dillon, E;Ziegler, MG
在人类唾液中很容易检测到儿茶酚胺，但其来源尚不清楚。去甲肾上腺素（NE）在唾液中在4 ℃下储存2小时是稳定的，但在25 ℃下储存1小时后降解11 +/- 3%。我们将3 H-NE静脉输注到人体中，并测量唾液和前臂静脉血浆中3 H-NE及其代谢物的水平（其血浆NE水平反映NE的局部摄取和释放两者）。唾液中的3 H-NE水平持续上升1小时，即使前臂血浆水平已平稳5分钟。到65分钟的输液的3 H-NE：非放射性NE的比例是相似的唾液和前臂静脉血浆。唾液和前臂静脉血浆中NE、肾上腺素（E）的比值在所有时间点相似。咀嚼引起流涎，酸至少增加了三倍的量NE，E和3 H-NE释放到唾液中每分钟，但减少了多达一半的唾液中的浓度。唾液NE水平在站立15分钟后不变，但在直立姿势1小时后增加了31%。我们的数据表明，人唾液中存在的NE来自血流和唾液交感神经。血液NE扩散到唾液中需要大约1小时才能完成的发现表明，唾液中的NE是交感神经活性急性变化的不良指标。All rights reserved.
Catecholamines are readily detectable in human saliva but their origin is unclear. Norepinephrine (NE) was stable in saliva stored at 4 degrees for 2 hours but 11 +/- 3% degraded after storage at 25 degrees for 1 hour. We intravenously infused 3H-NE into humans and measured levels of 3H-NE and its metabolites in both saliva and forearm venous plasma (a sire whose plasma NE levels reflect both local uptake and release of NE). 3H-NE levels in saliva continued to rise for 1 hour even though forearm plasma levels had plateaued by 5 min. By 65 min into the infusion the ratio of 3H-NE:nonradioactive NE was similar in saliva and forearm venous plasma. The ratio of NE,epinephrine (E) was similar in saliva and forearm venous plasma at all time points. Chewing induced salivation, acid at least tripled the amount of NE, E and 3H-NE released into saliva per minute, but decreased their concentration in saliva by as much as one half. Saliva NE level was unaltered after 15 min of standing but was increased by 31% after 1 hour of upright posture. Our data imply that the NE present in human saliva comes from both the bloodstream and from salivary sympathetic nerves, The finding that diffusion of blood NE into saliva takes roughly 1 hour to complete suggests that NE in saliva is a poor index of acute changes in sympathetic activity, (C) 2001 Elsevier Science Inc. All rights reserved.